Approbation of a New Model of Secondary Damage after Traumatic Brain Injury Based on Reprogrammed Rat Embryo Fibroblasts

Rykunova, E. B.; Mikeladze, M. A.; Utepova, I. A.; Chupakhin, O. N.; Guzhova, I. V.; Lazarev, V. F.

doi:10.1134/S1607672923700345

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Название:	Approbation of a New Model of Secondary Damage after Traumatic Brain Injury Based on Reprogrammed Rat Embryo Fibroblasts
Авторы:	Rykunova, E. B. Mikeladze, M. A. Utepova, I. A. Chupakhin, O. N. Guzhova, I. V. Lazarev, V. F.
Дата публикации:	2023
Издатель:	Pleiades Publishing
Библиографическое описание:	Rykunova, EB, Mikeladze, MA, Utepova, IA, Chupakhin, ON, Guzhova, IV & Lazarev, VF 2023, 'Approbation of a New Model of Secondary Damage after Traumatic Brain Injury Based on Reprogrammed Rat Embryo Fibroblasts', Doklady Biochemistry and Biophysics, Том. 511, № 1, стр. 235-239. https://doi.org/10.1134/S1607672923700345 Rykunova, E. B., Mikeladze, M. A., Utepova, I. A., Chupakhin, O. N., Guzhova, I. V., & Lazarev, V. F. (2023). Approbation of a New Model of Secondary Damage after Traumatic Brain Injury Based on Reprogrammed Rat Embryo Fibroblasts. Doklady Biochemistry and Biophysics, 511(1), 235-239. https://doi.org/10.1134/S1607672923700345
Аннотация:	Abstract: The paper presents a new model of secondary injuries after traumatic brain injury. The model is based on the cultivation of rat embryonic fibroblasts reprogrammed to a neuronal phenotype in the presence of cerebrospinal fluid from injured rats. The presented model was used to test the therapeutic effect of inducers of the synthesis of chaperones from the classes of pyrrolylazines and indolylazines, which have neuroprotective properties. © 2023, The Author(s).
Ключевые слова:	CEREBROSPINAL FLUID CHAPERONES HSP70 PYRROLYLAZINE AND INDOLYLAZINE DERIVATIVES SECONDARY INJURIES TRAUMATIC BRAIN INJURY ANIMAL BRAIN INJURY CEREBROSPINAL FLUID COMPLICATION NERVE CELL RAT TRAUMATIC BRAIN INJURY ANIMALS BRAIN INJURIES BRAIN INJURIES, TRAUMATIC NEURONS RATS
URI:	http://elar.urfu.ru/handle/10995/130854
Условия доступа:	info:eu-repo/semantics/openAccess cc-by
Текст лицензии:	https://creativecommons.org/licenses/by/4.0/
Идентификатор РИНЦ:	63462359
Идентификатор SCOPUS:	85174015731
Идентификатор WOS:	001086576900015
Идентификатор PURE:	46914084
ISSN:	1607-6729
DOI:	10.1134/S1607672923700345
Сведения о поддержке:	Ministry of Education and Science of the Russian Federation, Minobrnauka: 075-15-2021-683; Russian Science Foundation, RSF: 18-74-10087 This work was supported by the Russian Science Foundation, project no. 18-74-10087. Rat embryonic fibroblasts DFK-3 were obtained from the Vertebrate Cell Culture Collection core facility, which was supported by a grant from the Ministry of Education and Science of the Russian Federation (agreement no. 075-15-2021-683). Cells were cultured in DMEM medium (BioloT, Russia) supplemented with 10% fetal bovine serum (Gibco, United States) and antibiotics penicillin 100 units/mL and streptomycin 0.1 mg/mL (BioloT, Russia) at 37°C and 5% CO. 2
Карточка проекта РНФ:	18-74-10087
Располагается в коллекциях:	Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

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