1. Электронный научный архив УрФУ
  2. 00. Общеуниверситетские коллекции
  3. Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC
Please use this identifier to cite or link to this item: http://elar.urfu.ru/handle/10995/130854
Title: Approbation of a New Model of Secondary Damage after Traumatic Brain Injury Based on Reprogrammed Rat Embryo Fibroblasts
Authors: Rykunova, E. B.
Mikeladze, M. A.
Utepova, I. A.
Chupakhin, O. N.
Guzhova, I. V.
Lazarev, V. F.
Issue Date: 2023
Publisher: Pleiades Publishing
Citation: Rykunova, EB, Mikeladze, MA, Utepova, IA, Chupakhin, ON, Guzhova, IV & Lazarev, VF 2023, 'Approbation of a New Model of Secondary Damage after Traumatic Brain Injury Based on Reprogrammed Rat Embryo Fibroblasts', Doklady Biochemistry and Biophysics, Том. 511, № 1, стр. 235-239. https://doi.org/10.1134/S1607672923700345
Rykunova, E. B., Mikeladze, M. A., Utepova, I. A., Chupakhin, O. N., Guzhova, I. V., & Lazarev, V. F. (2023). Approbation of a New Model of Secondary Damage after Traumatic Brain Injury Based on Reprogrammed Rat Embryo Fibroblasts. Doklady Biochemistry and Biophysics, 511(1), 235-239. https://doi.org/10.1134/S1607672923700345
Abstract: Abstract: The paper presents a new model of secondary injuries after traumatic brain injury. The model is based on the cultivation of rat embryonic fibroblasts reprogrammed to a neuronal phenotype in the presence of cerebrospinal fluid from injured rats. The presented model was used to test the therapeutic effect of inducers of the synthesis of chaperones from the classes of pyrrolylazines and indolylazines, which have neuroprotective properties. © 2023, The Author(s).
Keywords: CEREBROSPINAL FLUID
CHAPERONES
HSP70
PYRROLYLAZINE AND INDOLYLAZINE DERIVATIVES
SECONDARY INJURIES
TRAUMATIC BRAIN INJURY
ANIMAL
BRAIN INJURY
CEREBROSPINAL FLUID
COMPLICATION
NERVE CELL
RAT
TRAUMATIC BRAIN INJURY
ANIMALS
BRAIN INJURIES
BRAIN INJURIES, TRAUMATIC
NEURONS
RATS
URI: http://elar.urfu.ru/handle/10995/130854
Access: info:eu-repo/semantics/openAccess
cc-by
License text: https://creativecommons.org/licenses/by/4.0/
RSCI ID: 63462359
SCOPUS ID: 85174015731
WOS ID: 001086576900015
PURE ID: 46914084
ISSN: 1607-6729
DOI: 10.1134/S1607672923700345
metadata.dc.description.sponsorship: Ministry of Education and Science of the Russian Federation, Minobrnauka: 075-15-2021-683; Russian Science Foundation, RSF: 18-74-10087
This work was supported by the Russian Science Foundation, project no. 18-74-10087.
Rat embryonic fibroblasts DFK-3 were obtained from the Vertebrate Cell Culture Collection core facility, which was supported by a grant from the Ministry of Education and Science of the Russian Federation (agreement no. 075-15-2021-683). Cells were cultured in DMEM medium (BioloT, Russia) supplemented with 10% fetal bovine serum (Gibco, United States) and antibiotics penicillin 100 units/mL and streptomycin 0.1 mg/mL (BioloT, Russia) at 37°C and 5% CO. 2
RSCF project card: 18-74-10087
Appears in Collections:Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

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