| Title: | Efficient synthesis of novel benzo[b][1,8]naphthyridin-4(1H)-ones and pyrido[2,3-b]quinoxalin-4(1H)-ones from alkynones and primary amines |
| Authors: | Iaroshenko, V. O.
Zahid, M.
Mkrtchyan, S.
Gevorgyan, A.
Altenburger, K.
Knepper, I.
Villinger, A.
Sosnovskikh, V. Y.
Langer, P. |
| Issue Date: | 2013 |
| Citation: | Efficient synthesis of novel benzo[b][1,8]naphthyridin-4(1H)-ones and pyrido[2,3-b]quinoxalin-4(1H)-ones from alkynones and primary amines / V. O. Iaroshenko, M. Zahid, S. Mkrtchyan [et al.] // Tetrahedron. — 2013. — Vol. 69. — № 10. — P. 2309-2318. |
| Abstract: | An efficient palladium-catalyzed cyclization of o-chlorohetaryl ynones with aliphatic and aromatic primary amines represents a simple access to a wide range of benzo[b][1,8]naphthyridin-4(1H)-one and pyrido[2,3-b]quinoxalin-4(1H)- one derivatives in good to excellent yields. © 2013 Elsevier Ltd. All rights reserved. |
| Keywords: | AMINES
BENZO[B][1,8]NAPHTHYRIDIN-4(1H)-ONES
O-CHLOROHETARYL YNONES
PALLADIUM-CATALYZED CYCLIZATION
PYRIDO[2,3-B]QUINOXALIN-4(1H)-ONES
1 (2 CHLOROBENZYL) 2 PHENYLBENZO[B][1,8]NAPHTHYRIDIN 4(1H) ONE
1 (2 FLUOROPHENYL) 2 PHENYLBENZO[B][1,8]NAPHTHYRIDIN 4(1H) ONE
1 (2 HYDROXYETHYL) 2 PHENYLBENZO[B][1,8]NAPHTHYRIDIN 4(1H) ONE
1 (2 HYDROXYETHYL) 2 PHENYLPYRIDO[2,3 B]QUINOXALIN 4(1H) ONE
1 (3 CHLOROQUINOXALIN 2 YL) 3 PHENYLPROP 2 YN 1 ONE
1 (3 CHLOROQUINOXALIN 2 YL)UNDEC 2 YN 1 ONE
1 (3 METHOXYBENZYL) 2 PHENYLBENZO[B][1,8]NAPHTHYRIDIN 4(1H) ONE
1 (3 MORPHOLINOPROPYL) 2 PHENYLBENZO[B][1,8]NAPHTHYRIDIN 4(1H) ONE
1 (3,4 DIMETHOXYPHENYL) 2 PHENYLBENZO[B][1,8]NAPHTHYRIDIN 4(1H) ONE
1 (3,5 DIMETHOXYPHENYL) 2 PHENYLBENZO[B][1,8]NAPHTHYRIDIN 4(1H) ONE
1 (4 ETHYLPHENYL) 2 PHENYLBENZO[B][1,8]NAPHTHYRIDIN 4(1H) ONE
1 (4 METHOXYBENZYL) 2 PHENYLBENZO[B][1,8]NAPHTHYRIDIN 4(1H) ONE
1 (4 METHOXYPHENYL) 2 PHENYLBENZO[B][1,8]NAPHTHYRIDIN 4(1H) ONE
1 [3 (1H IMIDAZOL 1 YL)PROPYL] 2 PHENYLBENZO[B][1,8]NAPHTHYRIDIN 4(1H) ONE
1 [4 (DIETHYLAMINO)PHENYL] 2 PHENYLBENZO[B][1,8]NAPHTHYRIDIN 4(1H) ONE
1 BENZYL 2 PHENYLBENZO[B][1,8]NAPHTHYRIDIN 4(1H) ONE
1 BENZYL 2 PHENYLPYRIDO[2,3 B]QUINOXALIN 4(1H) ONE
1 CYCLOHEXYL 2 PHENYLBENZO[B][1,8]NAPHTHYRIDIN 4(1H) ONE
1 CYCLOHEXYL 2 PHENYLPYRIDO[2,3 B]QUINOXALIN 4(1H) ONE
1 CYCLOPROPYL 2 PHENYLBENZO[B][1,8]NAPHTHYRIDIN 4(1H) ONE
1 HEPTYL 2 PHENYLBENZO[B][1,8]NAPHTHYRIDIN 4(1H) ONE
1 PHENETHYL 2 PHENYLBENZO[B][1,8]NAPHTHYRIDIN 4(1H) ONE
2 PHENYL 1 (2,4 DIMETHOXYPHENYL)BENZO[B][1,8]NAPHTHYRIDIN 4(1H) ONE
2 PHENYL 1 (3,4,5 TRIMETHOXYPHENYL)BENZO[B][1,8]NAPHTHYRIDIN 4(1H) ONE
2 PHENYL 1 (3,5 DIMETHYLPHENYL)BENZO[B][1,8]NAPHTHYRIDIN 4(1H) ONE
2 PHENYLBENZO[B][1,8]NAPHTHYRIDIN 4(1H) ONE
AROMATIC AMINE
PYRIDINE DERIVATIVE
QUINOXALINE DERIVATIVE
UNCLASSIFIED DRUG
UNINDEXED DRUG
AMINATION
ARTICLE
CARBON NUCLEAR MAGNETIC RESONANCE
COLUMN CHROMATOGRAPHY
CYCLIZATION
DRUG STRUCTURE
DRUG SYNTHESIS
MASS SPECTROMETRY
PRIORITY JOURNAL
PROTON NUCLEAR MAGNETIC RESONANCE |
| URI: | http://elar.urfu.ru/handle/10995/27090 |
| SCOPUS ID: | 84873413895 |
| WOS ID: | 000315321500011 |
| PURE ID: | 913764 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2013.01.008 |
| Appears in Collections: | Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC
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