1. Электронный научный архив УрФУ
  2. 00. Общеуниверситетские коллекции
  3. Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC
Please use this identifier to cite or link to this item: http://elar.urfu.ru/handle/10995/131317
Title: Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities
Authors: Kovalev, I. S.
Zyryanov, G. V.
Santra, S.
Majee, A.
Varaksin, M. V.
Charushin, V. N.
Issue Date: 2022
Publisher: MDPI
Citation: Kovalev, IS, Zyryanov, GV, Santra, S, Majee, A, Varaksin, MV & Charushin, VN 2022, 'Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities', Molecules, Том. 27, № 19, 6229. https://doi.org/10.3390/molecules27196229
Kovalev, I. S., Zyryanov, G. V., Santra, S., Majee, A., Varaksin, M. V., & Charushin, V. N. (2022). Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities. Molecules, 27(19), [6229]. https://doi.org/10.3390/molecules27196229
Abstract: Antimetabolites of folic acid represent a large group of drugs and drug candidates, including those for cancer chemotherapy. In this current review, the most common methods and approaches are presented for the synthesis of therapeutically significant antimetabolites of folic acid, which are Methotrexate (MTX), Raltitrexed (Tomudex, ZD1694), Pralatrexate, Pemetrexed, TNP-351, and Lometrexol. In addition, the applications or uses of these folic acid antimetabolites are also discussed. © 2022 by the authors.
Keywords: ANTIFOLATES
APPLICATIONS
DRUGS
FOLIC ACIDS
SYNTHESIS
URI: http://elar.urfu.ru/handle/10995/131317
Access: info:eu-repo/semantics/openAccess
cc-by
License text: https://creativecommons.org/licenses/by/4.0/
SCOPUS ID: 85139962002
WOS ID: 000866947400001
PURE ID: 31022645
14e5cbcd-17fa-4c3d-9fa4-cc0a4439055a
ISSN: 1420-3049
DOI: 10.3390/molecules27196229
Sponsorship: Ministry of Science, ICT and Future Planning, MSIP, (075-15-2022-1118)
Russian Science Foundation, RSF, (20-43-01004)
The analysis of synthetic approaches to antifolates was supported by the Russian Science Foundation (Project # 20-43-01004). The analysis of biological activity of antifolates was supported by the Ministry of Science and the Higher Education of RF (Ref. # 075-15-2022-1118, dated 29 June 2022).
RSCF project card: 20-43-01004
Appears in Collections:Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

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