Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines

Demin, A. M.; Vakhrushev, A. V.; Pershina, A. G.; Valova, M. S.; Efimova, L. V.; Syomchina, A. A.; Uimin, M. A.; Minin, A. S.; Levit, G. L.; Krasnov, V. P.; Charushin, V. N.

doi:10.3390/ijms23169093

Please use this identifier to cite or link to this item: http://elar.urfu.ru/handle/10995/118059

Title:	Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines
Authors:	Demin, A. M. Vakhrushev, A. V. Pershina, A. G. Valova, M. S. Efimova, L. V. Syomchina, A. A. Uimin, M. A. Minin, A. S. Levit, G. L. Krasnov, V. P. Charushin, V. N.
Issue Date:	2022
Publisher:	MDPI
Citation:	Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines / A. M. Demin, A. V. Vakhrushev, A. G. Pershina et al. // International Journal of Molecular Sciences. — 2022. — Vol. 23. — Iss. 16. — 9093.
Abstract:	Novel nanocomposite materials based on Fe3O4 magnetic nanoparticles (MNPs) coated with silica and covalently modified by [(3-triethoxysilyl)propyl]succinic acid–polyethylene glycol (PEG 3000) conjugate, which provides a high level of doxorubicin (Dox) loading, were obtained. The efficiency of Dox desorption from the surface of nanomaterials under the action of an alternating magnetic field (AMF) in acidic and neutral media was evaluated. Their high cytotoxicity against tumor cells, as well as the drug release upon application of AMF, which leads to an increase in the cytotoxic effect, was demonstrated. © 2022 by the authors.
Keywords:	ALTERNATING MAGNETIC FIELD DOXORUBICIN DRUG-DELIVERY MAGNETIC NANOPARTICLES PEG SIO2 TUMOR CELLS DOXORUBICIN DRUG CARRIER MACROGOL MAGNETITE NANOPARTICLE NANOPARTICLE SILICON DIOXIDE CELL LINE HUMAN MAGNETISM NEOPLASM PH CELL LINE DOXORUBICIN DRUG CARRIERS HUMANS HYDROGEN-ION CONCENTRATION MAGNETIC PHENOMENA MAGNETITE NANOPARTICLES NANOPARTICLES NEOPLASMS POLYETHYLENE GLYCOLS SILICON DIOXIDE
URI:	http://elar.urfu.ru/handle/10995/118059
Access:	info:eu-repo/semantics/openAccess
SCOPUS ID:	85136615931
WOS ID:	000845657600001
PURE ID:	30850954
ISSN:	16616596
DOI:	10.3390/ijms23169093
Sponsorship:	Ministry of Education and Science of the Russian Federation, Minobrnauka: 075-15-2020-777 This research was funded by the Ministry of Science and Higher Education of the Russian Federation, grant number 075-15-2020-777.
Appears in Collections:	Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

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