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http://elar.urfu.ru/handle/10995/111111
Название: | Astaxantin and Isoflavones Inhibit Benign Prostatic Hyperplasia in Rats by Reducing Oxidative Stress and Normalizing Ca/Mg Balance |
Авторы: | Semenov, A. L. Gubareva, E. A. Ermakova, E. D. Dorofeeva, A. A. Tumanyan, I. A. Radetskaya, E. A. Yurova, M. N. Aboushanab, S. A. Kanwugu, O. N. Fedoros, E. I. Panchenko, A. V. |
Дата публикации: | 2021 |
Издатель: | MDPI MDPI AG |
Библиографическое описание: | Astaxantin and Isoflavones Inhibit Benign Prostatic Hyperplasia in Rats by Reducing Oxidative Stress and Normalizing Ca/Mg Balance / A. L. Semenov, E. A. Gubareva, E. D. Ermakova et al. // Plants. — 2021. — Vol. 10. — Iss. 12. — 2735. |
Аннотация: | Benign prostatic hyperplasia (BPH) is a common pathology among aging men. Despite the broad pharmacological interventions, the available remedies to treat BPH are yet not devoid of side effects. Herbal compounds are suggested to be an alternative option for the BPH treatment. In our study, we evaluated the effect of kudzu isoflavones and astaxanthin on the BPH animal model. The animals were randomly divided into five groups: control; testosterone-induced BPH group; and three BPH-induced groups, which received intragastrically for 28 days finasteride (5 mg/kg) as a positive control, isoflavones (200 mg/kg), and astaxanthin (25 mg/kg). BPH was induced by castration of animals and subsequent subcutaneous injections of prolonged testosterone (25 mg/kg). Prostate index and histology, biochemical parameters, and antioxidant activity were evaluated. A significant decrease in prostate weight, immunohistochemical markers, and normalization of prostate Ca/Mg ratio was found in all treatment groups. Astaxanthin treatment also resulted in decreased epithelial proliferation and normalized superoxide dismutase activity. In conclusion, both isoflavones and astaxanthin inhibited BPH development at a level comparable to finasteride in terms of prostate weight, prostatic epithelium proliferation, and prostate tissue cumulative histology score. These results suggest that isoflavones and especially astaxanthin could serve as a potential alternative therapy to treat BHP. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Ключевые слова: | ASTAXANTHIN BENIGN PROSTATIC HYPERPLASIA CALCIUM ISOFLAVONES KUDZU MAGNESIUM OXIDATIVE STRESS P. RHODOZYMA RATS TESTOSTERONE |
URI: | http://elar.urfu.ru/handle/10995/111111 |
Условия доступа: | info:eu-repo/semantics/openAccess |
Идентификатор РИНЦ: | 47540345 |
Идентификатор SCOPUS: | 85121003597 |
Идентификатор WOS: | 000738240400001 |
Идентификатор PURE: | 29148753 |
ISSN: | 2223-7747 |
DOI: | 10.3390/plants10122735 |
Сведения о поддержке: | Funding: This research was funded by Russian Science Foundation, grant number 20-65-47025. |
Карточка проекта РНФ: | 20-65-47025 |
Располагается в коллекциях: | Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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2-s2.0-85121003597.pdf | 2,49 MB | Adobe PDF | Просмотреть/Открыть |
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