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dc.contributor.authorSemenov, A. L.en
dc.contributor.authorGubareva, E. A.en
dc.contributor.authorErmakova, E. D.en
dc.contributor.authorDorofeeva, A. A.en
dc.contributor.authorTumanyan, I. A.en
dc.contributor.authorRadetskaya, E. A.en
dc.contributor.authorYurova, M. N.en
dc.contributor.authorAboushanab, S. A.en
dc.contributor.authorKanwugu, O. N.en
dc.contributor.authorFedoros, E. I.en
dc.contributor.authorPanchenko, A. V.en
dc.date.accessioned2022-05-12T08:13:06Z-
dc.date.available2022-05-12T08:13:06Z-
dc.date.issued2021-
dc.identifier.citationAstaxantin and Isoflavones Inhibit Benign Prostatic Hyperplasia in Rats by Reducing Oxidative Stress and Normalizing Ca/Mg Balance / A. L. Semenov, E. A. Gubareva, E. D. Ermakova et al. // Plants. — 2021. — Vol. 10. — Iss. 12. — 2735.en
dc.identifier.issn2223-7747-
dc.identifier.otherAll Open Access, Gold, Green3
dc.identifier.urihttp://elar.urfu.ru/handle/10995/111111-
dc.description.abstractBenign prostatic hyperplasia (BPH) is a common pathology among aging men. Despite the broad pharmacological interventions, the available remedies to treat BPH are yet not devoid of side effects. Herbal compounds are suggested to be an alternative option for the BPH treatment. In our study, we evaluated the effect of kudzu isoflavones and astaxanthin on the BPH animal model. The animals were randomly divided into five groups: control; testosterone-induced BPH group; and three BPH-induced groups, which received intragastrically for 28 days finasteride (5 mg/kg) as a positive control, isoflavones (200 mg/kg), and astaxanthin (25 mg/kg). BPH was induced by castration of animals and subsequent subcutaneous injections of prolonged testosterone (25 mg/kg). Prostate index and histology, biochemical parameters, and antioxidant activity were evaluated. A significant decrease in prostate weight, immunohistochemical markers, and normalization of prostate Ca/Mg ratio was found in all treatment groups. Astaxanthin treatment also resulted in decreased epithelial proliferation and normalized superoxide dismutase activity. In conclusion, both isoflavones and astaxanthin inhibited BPH development at a level comparable to finasteride in terms of prostate weight, prostatic epithelium proliferation, and prostate tissue cumulative histology score. These results suggest that isoflavones and especially astaxanthin could serve as a potential alternative therapy to treat BHP. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.en
dc.description.sponsorshipFunding: This research was funded by Russian Science Foundation, grant number 20-65-47025.en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherMDPIen1
dc.publisherMDPI AGen
dc.relationinfo:eu-repo/grantAgreement/RSF//20-65-47025en
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.sourcePlants2
dc.sourcePlantsen
dc.subjectASTAXANTHINen
dc.subjectBENIGN PROSTATIC HYPERPLASIAen
dc.subjectCALCIUMen
dc.subjectISOFLAVONESen
dc.subjectKUDZUen
dc.subjectMAGNESIUMen
dc.subjectOXIDATIVE STRESSen
dc.subjectP. RHODOZYMAen
dc.subjectRATSen
dc.subjectTESTOSTERONEen
dc.titleAstaxantin and Isoflavones Inhibit Benign Prostatic Hyperplasia in Rats by Reducing Oxidative Stress and Normalizing Ca/Mg Balanceen
dc.typeArticleen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeinfo:eu-repo/semantics/publishedVersionen
dc.identifier.scopus85121003597-
local.contributor.employeeSemenov, A.L., N.N. Petrov National Medical Research Center of Oncology, Leningradskaya str, 68, St. Petersburg, 197758, Russian Federation; Gubareva, E.A., N.N. Petrov National Medical Research Center of Oncology, Leningradskaya str, 68, St. Petersburg, 197758, Russian Federation; Ermakova, E.D., N.N. Petrov National Medical Research Center of Oncology, Leningradskaya str, 68, St. Petersburg, 197758, Russian Federation, Institute of Biomedical Systems and Biotechnology, Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya, 29, St. Petersburg, 195251, Russian Federation; Dorofeeva, A.A., N.N. Petrov National Medical Research Center of Oncology, Leningradskaya str, 68, St. Petersburg, 197758, Russian Federation, Institute of Biomedical Systems and Biotechnology, Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya, 29, St. Petersburg, 195251, Russian Federation; Tumanyan, I.A., N.N. Petrov National Medical Research Center of Oncology, Leningradskaya str, 68, St. Petersburg, 197758, Russian Federation, SCAMT Institute, ITMO University, Lomonosova St. 9, St. Petersburg, 191002, Russian Federation; Radetskaya, E.A., N.N. Petrov National Medical Research Center of Oncology, Leningradskaya str, 68, St. Petersburg, 197758, Russian Federation; Yurova, M.N., N.N. Petrov National Medical Research Center of Oncology, Leningradskaya str, 68, St. Petersburg, 197758, Russian Federation; Aboushanab, S.A., Institute of Chemical Technology, Ural Federal University Named after The First President of Russia B. N. Yeltsin, Mira 19, Yekaterinburg, 620002, Russian Federation; Kanwugu, O.N., Institute of Chemical Technology, Ural Federal University Named after The First President of Russia B. N. Yeltsin, Mira 19, Yekaterinburg, 620002, Russian Federation; Fedoros, E.I., N.N. Petrov National Medical Research Center of Oncology, Leningradskaya str, 68, St. Petersburg, 197758, Russian Federation; Panchenko, A.V., N.N. Petrov National Medical Research Center of Oncology, Leningradskaya str, 68, St. Petersburg, 197758, Russian Federationen
local.issue12-
local.volume10-
local.contributor.departmentN.N. Petrov National Medical Research Center of Oncology, Leningradskaya str, 68, St. Petersburg, 197758, Russian Federation; Institute of Biomedical Systems and Biotechnology, Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya, 29, St. Petersburg, 195251, Russian Federation; SCAMT Institute, ITMO University, Lomonosova St. 9, St. Petersburg, 191002, Russian Federation; Institute of Chemical Technology, Ural Federal University Named after The First President of Russia B. N. Yeltsin, Mira 19, Yekaterinburg, 620002, Russian Federationen
local.identifier.pure29148753-
local.description.order2735-
local.identifier.eid2-s2.0-85121003597-
local.fund.rsf20-65-47025-
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