Zebrafish as a Model of Neurodevelopmental Disorders

de, Abreu, M. S.; Genario, R.; Giacomini, A. C. V. V.; Demin, K. A.; Lakstygal, A. M.; Amstislavskaya, T. G.; Fontana, B. D.; Parker, M. O.; Kalueff, A. V.

doi:10.1016/j.neuroscience.2019.08.034

Please use this identifier to cite or link to this item: http://elar.urfu.ru/handle/10995/101653

Title:	Zebrafish as a Model of Neurodevelopmental Disorders
Authors:	de, Abreu, M. S. Genario, R. Giacomini, A. C. V. V. Demin, K. A. Lakstygal, A. M. Amstislavskaya, T. G. Fontana, B. D. Parker, M. O. Kalueff, A. V.
Issue Date:	2020
Publisher:	Elsevier Ltd
Citation:	Zebrafish as a Model of Neurodevelopmental Disorders / M. S. de Abreu, R. Genario, A. C. V. V. Giacomini, et al. — DOI 10.1016/j.neuroscience.2019.08.034 // Neuroscience. — 2020. — Vol. 445. — P. 3-11.
Abstract:	Neurodevelopmental disorders (NDDs) caused by aberrant brain growth and development are life-long, debilitating illnesses that markedly impair the quality of life. Animal models are a valuable tool for studying NDD pathobiology and therapies. Mounting evidence suggests the zebrafish (Danio rerio) as a useful model organism to study NDDs, possessing both high physiological homology to humans and sensitivity to pharmacological and genetic manipulations. Here, we summarize experimental models of NDDs in zebrafish and highlight the growing translational significance of zebrafish NDD-related phenotypes. We also emphasize the need in further development of zebrafish models of NDDs to improve our understanding of their pathogenesis and therapeutic treatments. © 2019 IBRO
Keywords:	ANIMAL MODELS ATTENTION-DEFICIT/HYPERACTIVITY DISORDER AUTISM GENETIC MODELS NEURODEVELOPMENT VALPROIC ACID ATTENTION DEFICIT DISORDER BEHAVIOR DISORDER DISEASE MODEL ENVIRONMENTAL EXPOSURE ENVIRONMENTAL FACTOR GENE IDENTIFICATION GENE MUTATION GENETIC RISK HUMAN MENTAL DISEASE MICROCEPHALY NONHUMAN PATHOGENESIS PHENOTYPE PRENATAL EXPOSURE PRIORITY JOURNAL REVIEW SCHIZOPHRENIA SIGNAL TRANSDUCTION ZEBRA FISH ANIMAL ANIMAL MODEL BRAIN DISEASE MODEL QUALITY OF LIFE ANIMALS BRAIN DISEASE MODELS, ANIMAL HUMANS MODELS, ANIMAL NEURODEVELOPMENTAL DISORDERS QUALITY OF LIFE ZEBRAFISH
URI:	http://elar.urfu.ru/handle/10995/101653
Access:	info:eu-repo/semantics/openAccess
SCOPUS ID:	85075860800
WOS ID:	000573888400002
PURE ID:	326464cf-9729-4c20-b3bc-724dc6d83c98 13909898
ISSN:	3064522
DOI:	10.1016/j.neuroscience.2019.08.034
Sponsorship:	This research is supported by the Russian Science Foundation grant 19-05-00053. KAD is supported by the Russian Foundation for Basic Research grant 18‐34‐00996, the President of Russia PhD Fellowship and the SPSU Rector's Productivity Fellowship for PhD students. ACVVG is supported by the Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS) research fellowships 17/2551-0001-269-0. AVK is the President of the International Stress and Behavior Society (ISBS, www.stress-and-behavior .com) and the Chair of the International Zebrafish Neuroscience Research Consortium (ZNRC) that coordinated this multi-laboratory collaborative project.
RSCF project card:	19-05-00053
Appears in Collections:	Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

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