Insulin-producing system at diabetes mellitus type 2

Abstract

In T2D deficiency of insulin can be compensated for by the formation of new cells, producing insulin. Reprogramming of hepatocytes and cells of exocrine part of the pancreas into insulin+ cells is a potentially approach to generate new insulin-producing cells. An increase both the number of insulin+ hepatocytes and quantity in them of a transcription factor PDX1, which regulates expression of insulin gene, is a perspective way in in the development of new methods and approaches in the treatment of diabetes mellitus.