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http://elar.urfu.ru/handle/10995/92702
Название: | Changes in rat myocardium contractility under subchronic intoxication with lead and cadmium salts administered alone or in combination |
Авторы: | Protsenko, Y. L. Klinova, S. V. Gerzen, O. P. Privalova, L. I. Minigalieva, I. A. Balakin, A. A. Lookin, O. N. Lisin, R. V. Butova, K. A. Nabiev, S. R. Katsnelson, L. B. Nikitina, L. V. Katsnelson, B. A. |
Дата публикации: | 2020 |
Издатель: | Elsevier Inc. |
Библиографическое описание: | Changes in rat myocardium contractility under subchronic intoxication with lead and cadmium salts administered alone or in combination / Y. L. Protsenko, S. V. Klinova, O. P. Gerzen, L. I. Privalova, et al.. — DOI 10.1016/j.toxrep.2020.03.001 // Toxicology Reports. — 2020. — Iss. 7. — P. 433-442. |
Аннотация: | Subchronic intoxications induced in male rats by repeated intraperitoneal injections of lead acetate and cadmium chloride, administered either alone or in combination, are shown to affect the biochemical, cytological and morphometric parameters of blood, liver, heart and kidneys. The single twitch parameters of myocardial trabecular and papillary muscle preparations were measured in the isometric regime to identify changes in the heterometric (length-force) and chronoinotropic (frequency-force) contractility regulation systems. Differences in the responses of these systems in trabecules and papillary muscles to the above intoxications are shown. A number of myocardium mechanical characteristics changing in rats under the effect of a combined lead-cadmium intoxication and increased proportion of α-myosin heavy chains were observed to normalize fully or partially if such intoxication was induced against background administration of a proposed bioprotective complex. Based on the experimental results and literature data, some assumptions are suggested concerning the mechanisms of the cardiotoxic effects produced by lead and cadmium. © 2020 |
Ключевые слова: | BIOPROTECTORS CADMIUM CARDIOTOXICITY LEAD MYOCARDIUM CONTRACTILITY MYOSIN PAPILLARY MUSCLES TRABECULES ACETYLCYSTEINE ALPHA TOCOPHEROL ASCORBIC ACID CADMIUM CHLORIDE CALCIUM COLECALCIFEROL GLUTAMATE SODIUM INORGANIC SALT IODINE IRON LEAD ACETATE MAGNESIUM MYOSIN HEAVY CHAIN ALPHA MYOSIN HEAVY CHAIN BETA OMEGA 3 FATTY ACID RETINOL RUTOSIDE SELENIUM VITAMIN B GROUP ANIMAL EXPERIMENT ANIMAL MODEL ARTICLE BLOOD ANALYSIS CADMIUM POISONING CARDIAC MUSCLE CARDIOTOXICITY CHEMICAL PARAMETERS CONTROLLED STUDY GENOTOXICITY HEART MUSCLE CONTRACTILITY HEART PAPILLARY MUSCLE HEART TISSUE HEART VENTRICLE HYPERTROPHY ISOMETRICS KIDNEY TISSUE LEAD POISONING LIVER TISSUE MALE MUSCLE ISOMETRIC CONTRACTION MUSCLE RELAXATION MUSCLE TWITCH NONHUMAN RAT |
URI: | http://elar.urfu.ru/handle/10995/92702 |
Условия доступа: | info:eu-repo/semantics/openAccess |
Идентификатор SCOPUS: | 85081009718 |
Идентификатор WOS: | 000604357600018 |
Идентификатор PURE: | 12437034 |
ISSN: | 22147500 |
DOI: | 10.1016/j.toxrep.2020.03.001 |
Сведения о поддержке: | AAAA-A18-118020590031-8, AAAA-A18-118020590031 The work was carried out partly within the framework of the IIF UrB RAS theme No AAAA-A18-118020590031-8 and AAAA-A18-118020590031. This work was performed using the equipment of the Shared Research Center of Scientific Equipment SRC IIP UrB RAS. |
Располагается в коллекциях: | Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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10.1016-j.toxrep.2020.03.001.pdf | 1,19 MB | Adobe PDF | Просмотреть/Открыть |
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