Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/92702
Title: Changes in rat myocardium contractility under subchronic intoxication with lead and cadmium salts administered alone or in combination
Authors: Protsenko, Y. L.
Klinova, S. V.
Gerzen, O. P.
Privalova, L. I.
Minigalieva, I. A.
Balakin, A. A.
Lookin, O. N.
Lisin, R. V.
Butova, K. A.
Nabiev, S. R.
Katsnelson, L. B.
Nikitina, L. V.
Katsnelson, B. A.
Issue Date: 2020
Publisher: Elsevier Inc.
Citation: Changes in rat myocardium contractility under subchronic intoxication with lead and cadmium salts administered alone or in combination / Y. L. Protsenko, S. V. Klinova, O. P. Gerzen, L. I. Privalova, et al.. — DOI 10.1016/j.toxrep.2020.03.001 // Toxicology Reports. — 2020. — Iss. 7. — P. 433-442.
Abstract: Subchronic intoxications induced in male rats by repeated intraperitoneal injections of lead acetate and cadmium chloride, administered either alone or in combination, are shown to affect the biochemical, cytological and morphometric parameters of blood, liver, heart and kidneys. The single twitch parameters of myocardial trabecular and papillary muscle preparations were measured in the isometric regime to identify changes in the heterometric (length-force) and chronoinotropic (frequency-force) contractility regulation systems. Differences in the responses of these systems in trabecules and papillary muscles to the above intoxications are shown. A number of myocardium mechanical characteristics changing in rats under the effect of a combined lead-cadmium intoxication and increased proportion of α-myosin heavy chains were observed to normalize fully or partially if such intoxication was induced against background administration of a proposed bioprotective complex. Based on the experimental results and literature data, some assumptions are suggested concerning the mechanisms of the cardiotoxic effects produced by lead and cadmium. © 2020
Keywords: BIOPROTECTORS
CADMIUM
CARDIOTOXICITY
LEAD
MYOCARDIUM CONTRACTILITY
MYOSIN
PAPILLARY MUSCLES
TRABECULES
ACETYLCYSTEINE
ALPHA TOCOPHEROL
ASCORBIC ACID
CADMIUM CHLORIDE
CALCIUM
COLECALCIFEROL
GLUTAMATE SODIUM
INORGANIC SALT
IODINE
IRON
LEAD ACETATE
MAGNESIUM
MYOSIN HEAVY CHAIN ALPHA
MYOSIN HEAVY CHAIN BETA
OMEGA 3 FATTY ACID
RETINOL
RUTOSIDE
SELENIUM
VITAMIN B GROUP
ANIMAL EXPERIMENT
ANIMAL MODEL
ARTICLE
BLOOD ANALYSIS
CADMIUM POISONING
CARDIAC MUSCLE
CARDIOTOXICITY
CHEMICAL PARAMETERS
CONTROLLED STUDY
GENOTOXICITY
HEART MUSCLE CONTRACTILITY
HEART PAPILLARY MUSCLE
HEART TISSUE
HEART VENTRICLE HYPERTROPHY
ISOMETRICS
KIDNEY TISSUE
LEAD POISONING
LIVER TISSUE
MALE
MUSCLE ISOMETRIC CONTRACTION
MUSCLE RELAXATION
MUSCLE TWITCH
NONHUMAN
RAT
URI: http://hdl.handle.net/10995/92702
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85081009718
PURE ID: 12437034
ISSN: 22147500
DOI: 10.1016/j.toxrep.2020.03.001
metadata.dc.description.sponsorship: AAAA-A18-118020590031-8, AAAA-A18-118020590031
The work was carried out partly within the framework of the IIF UrB RAS theme No AAAA-A18-118020590031-8 and AAAA-A18-118020590031. This work was performed using the equipment of the Shared Research Center of Scientific Equipment SRC IIP UrB RAS.
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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