Please use this identifier to cite or link to this item: http://elar.urfu.ru/handle/10995/92672
Title: An audit of uncertainty in multi-scale cardiac electrophysiology models
Authors: Clayton, R. H.
Aboelkassem, Y.
Cantwell, C. D.
Corrado, C.
Delhaas, T.
Huberts, W.
Lei, C. L.
Ni, H.
Panfilov, A. V.
Roney, C.
Dos, Santos, R. W.
Issue Date: 2020
Publisher: NLM (Medline)
Citation: An audit of uncertainty in multi-scale cardiac electrophysiology models / R. H. Clayton, Y. Aboelkassem, C. D. Cantwell, C. Corrado, et al.. — DOI 10.1098/rsta.2019.0335 // Philosophical transactions. Series A, Mathematical, physical, and engineering sciences. — 2020. — Vol. 2173. — Iss. 378. — P. 20190335.
Abstract: Models of electrical activation and recovery in cardiac cells and tissue have become valuable research tools, and are beginning to be used in safety-critical applications including guidance for clinical procedures and for drug safety assessment. As a consequence, there is an urgent need for a more detailed and quantitative understanding of the ways that uncertainty and variability influence model predictions. In this paper, we review the sources of uncertainty in these models at different spatial scales, discuss how uncertainties are communicated across scales, and begin to assess their relative importance. We conclude by highlighting important challenges that continue to face the cardiac modelling community, identifying open questions, and making recommendations for future studies. This article is part of the theme issue 'Uncertainty quantification in cardiac and cardiovascular modelling and simulation'.
Keywords: CARDIAC ELECTROPHYSIOLOGY
MULTISCALE MODEL
UNCERTAINTY QUANTIFICATION
URI: http://elar.urfu.ru/handle/10995/92672
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85085459138
WOS ID: 000537137000010
PURE ID: 12906502
ISSN: 14712962
DOI: 10.1098/rsta.2019.0335
Appears in Collections:Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

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