Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/90498
Title: Transmural cellular heterogeneity in myocardial electromechanics
Authors: Khokhlova, A.
Balakina-Vikulova, N.
Katsnelson, L.
Iribe, G.
Solovyova, O.
Issue Date: 2018
Publisher: Springer Tokyo
Citation: Transmural cellular heterogeneity in myocardial electromechanics / A. Khokhlova, N. Balakina-Vikulova, L. Katsnelson, G. Iribe, et al. . — DOI 10.1007/s12576-017-0541-0 // Journal of Physiological Sciences. — 2018. — Vol. 4. — Iss. 68. — P. 387-413.
Abstract: Myocardial heterogeneity is an attribute of the normal heart. We have developed integrative models of cardiomyocytes from the subendocardial (ENDO) and subepicardial (EPI) ventricular regions that take into account experimental data on specific regional features of intracellular electromechanical coupling in the guinea pig heart. The models adequately simulate experimental data on the differences in the action potential and contraction between the ENDO and EPI cells. The modeling results predict that heterogeneity in the parameters of calcium handling and myofilament mechanics in isolated ENDO and EPI cardiomyocytes are essential to produce the differences in Ca2+ transients and contraction profiles via cooperative mechanisms of mechano-calcium-electric feedback and may further slightly modulate transmural differences in the electrical properties between the cells. Simulation results predict that ENDO cells have greater sensitivity to changes in the mechanical load than EPI cells. These data are important for understanding the behavior of cardiomyocytes in the intact heart. © 2017, The Physiological Society of Japan and Springer Japan.
Keywords: CARDIAC MODELING
CARDIAC TRANSMURAL HETEROGENEITY
CARDIOMYOCYTE
ELECTROMECHANICAL COUPLING
MECHANO-CALCIUM-ELECTRIC FEEDBACK
CALCIUM
ACTION POTENTIAL
ANIMAL
BIOLOGICAL MODEL
BIOMECHANICS
CARDIAC MUSCLE
CARDIAC MUSCLE CELL
GUINEA PIG
HEART CONTRACTION
METABOLISM
PHYSIOLOGY
ACTION POTENTIALS
ANIMALS
BIOMECHANICAL PHENOMENA
CALCIUM
GUINEA PIGS
MODELS, CARDIOVASCULAR
MYOCARDIAL CONTRACTION
MYOCARDIUM
MYOCYTES, CARDIAC
URI: http://hdl.handle.net/10995/90498
https://elar.urfu.ru/handle/10995/90498
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85016422654
WOS ID: 000434180700008
PURE ID: 7417245
ISSN: 1880-6546
DOI: 10.1007/s12576-017-0541-0
metadata.dc.description.sponsorship: Japan Society for the Promotion of Science, JSPS: 16K12878
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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