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  3. Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC
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dc.contributor.authorKhokhlova, A.en
dc.contributor.authorBalakina-Vikulova, N.en
dc.contributor.authorKatsnelson, L.en
dc.contributor.authorIribe, G.en
dc.contributor.authorSolovyova, O.en
dc.date.accessioned2020-09-29T09:47:34Z-
dc.date.available2020-09-29T09:47:34Z-
dc.date.issued2018-
dc.identifier.citationTransmural cellular heterogeneity in myocardial electromechanics / A. Khokhlova, N. Balakina-Vikulova, L. Katsnelson, G. Iribe, et al. . — DOI 10.1007/s12576-017-0541-0 // Journal of Physiological Sciences. — 2018. — Vol. 4. — Iss. 68. — P. 387-413.en
dc.identifier.issn1880-6546-
dc.identifier.otherhttps://jps.biomedcentral.com/track/pdf/10.1007/s12576-017-0541-0pdf
dc.identifier.other1good_DOI
dc.identifier.other6245f2f6-33c2-4136-ba97-0d71d16bb3fdpure_uuid
dc.identifier.otherhttp://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85016422654m
dc.identifier.urihttp://elar.urfu.ru/handle/10995/90498-
dc.description.abstractMyocardial heterogeneity is an attribute of the normal heart. We have developed integrative models of cardiomyocytes from the subendocardial (ENDO) and subepicardial (EPI) ventricular regions that take into account experimental data on specific regional features of intracellular electromechanical coupling in the guinea pig heart. The models adequately simulate experimental data on the differences in the action potential and contraction between the ENDO and EPI cells. The modeling results predict that heterogeneity in the parameters of calcium handling and myofilament mechanics in isolated ENDO and EPI cardiomyocytes are essential to produce the differences in Ca2+ transients and contraction profiles via cooperative mechanisms of mechano-calcium-electric feedback and may further slightly modulate transmural differences in the electrical properties between the cells. Simulation results predict that ENDO cells have greater sensitivity to changes in the mechanical load than EPI cells. These data are important for understanding the behavior of cardiomyocytes in the intact heart. © 2017, The Physiological Society of Japan and Springer Japan.en
dc.description.sponsorshipJapan Society for the Promotion of Science, JSPS: 16K12878en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherSpringer Tokyoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.sourceJournal of Physiological Sciencesen
dc.subjectCARDIAC MODELINGen
dc.subjectCARDIAC TRANSMURAL HETEROGENEITYen
dc.subjectCARDIOMYOCYTEen
dc.subjectELECTROMECHANICAL COUPLINGen
dc.subjectMECHANO-CALCIUM-ELECTRIC FEEDBACKen
dc.subjectCALCIUMen
dc.subjectACTION POTENTIALen
dc.subjectANIMALen
dc.subjectBIOLOGICAL MODELen
dc.subjectBIOMECHANICSen
dc.subjectCARDIAC MUSCLEen
dc.subjectCARDIAC MUSCLE CELLen
dc.subjectGUINEA PIGen
dc.subjectHEART CONTRACTIONen
dc.subjectMETABOLISMen
dc.subjectPHYSIOLOGYen
dc.subjectACTION POTENTIALSen
dc.subjectANIMALSen
dc.subjectBIOMECHANICAL PHENOMENAen
dc.subjectCALCIUMen
dc.subjectGUINEA PIGSen
dc.subjectMODELS, CARDIOVASCULARen
dc.subjectMYOCARDIAL CONTRACTIONen
dc.subjectMYOCARDIUMen
dc.subjectMYOCYTES, CARDIACen
dc.titleTransmural cellular heterogeneity in myocardial electromechanicsen
dc.typeArticleen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeinfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.1007/s12576-017-0541-0-
dc.identifier.scopus85016422654-
local.affiliationUral Federal University, Ekaterinburg, Russian Federationen
local.affiliationInstitute of Immunology and Physiology, Russian Academy of Sciences, 106 Pervomayskaya, Ekaterinburg, 620049, Russian Federationen
local.affiliationOkayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japanen
local.contributor.employeeKhokhlova, A., Ural Federal University, Ekaterinburg, Russian Federation, Institute of Immunology and Physiology, Russian Academy of Sciences, 106 Pervomayskaya, Ekaterinburg, 620049, Russian Federationru
local.contributor.employeeBalakina-Vikulova, N., Ural Federal University, Ekaterinburg, Russian Federation, Institute of Immunology and Physiology, Russian Academy of Sciences, 106 Pervomayskaya, Ekaterinburg, 620049, Russian Federationru
local.contributor.employeeKatsnelson, L., Ural Federal University, Ekaterinburg, Russian Federation, Institute of Immunology and Physiology, Russian Academy of Sciences, 106 Pervomayskaya, Ekaterinburg, 620049, Russian Federationru
local.contributor.employeeIribe, G., Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japanru
local.contributor.employeeSolovyova, O., Ural Federal University, Ekaterinburg, Russian Federation, Institute of Immunology and Physiology, Russian Academy of Sciences, 106 Pervomayskaya, Ekaterinburg, 620049, Russian Federationru
local.description.firstpage387-
local.description.lastpage413-
local.issue68-
local.volume4-
dc.identifier.wos000434180700008-
local.identifier.pure7417245-
local.identifier.eid2-s2.0-85016422654-
local.identifier.wosWOS:000434180700008-
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