Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/90450
Title: Manifestation of systemic toxicity in rats after a short-time inhalation of lead oxide nanoparticles
Authors: Sutunkova, M. P.
Solovyeva, S. N.
Chernyshov, I. N.
Klinova, S. V.
Gurvich, V. B.
Shur, V. Y.
Shishkina, E. V.
Zubarev, I. V.
Privalova, L. I.
Katsnelson, B. A.
Issue Date: 2020
Publisher: MDPI AG
Citation: Manifestation of systemic toxicity in rats after a short-time inhalation of lead oxide nanoparticles / M. P. Sutunkova, S. N. Solovyeva, I. N. Chernyshov, S. V. Klinova, et al. . — DOI 10.3390/ijms21030690 // International Journal of Molecular Sciences. — 2020. — Vol. 3. — Iss. 21. — 690.
Abstract: Outbred female rats were exposed to inhalation of lead oxide nanoparticle aerosol produced right then and there at a concentration of 1.30 ± 0.10 mg/m3 during 5 days for 4 h a day in a nose-only setup. A control group of rats were sham-exposed in parallel under similar conditions. Even this short-time exposure of a relatively low level was associated with nanoparticles retention demonstrable by transmission electron microscopy in the lungs and the olfactory brain. Some impairments were found in the organism’s status in the exposed group, some of which might be considered lead-specific toxicological outcomes (in particular, increase in reticulocytes proportion, in δ-aminolevulinic acid (δ-ALA) urine excretion, and the arterial hypertension’s development). © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords: INHALATION EXPOSURE
LEAD OXIDE
NANOPARTICLES
TOXICITY
ALBUMIN
ALKALINE PHOSPHATASE
AMYLASE
ASPARTATE AMINOTRANSFERASE
BRAIN NATRIURETIC PEPTIDE
CATALASE
CERULOPLASMIN
COPROPORPHYRIN
CREATININE
ENDOTHELIN 1
GAMMA GLUTAMYLTRANSFERASE
GLOBULIN
GLUCOSE
GLUTATHIONE
HEMOGLOBIN
LACTATE DEHYDROGENASE
LEAD OXIDE NANOPARTICLE
MALONALDEHYDE
METAL NANOPARTICLE
MYOGLOBIN
PROTEIN
TROPONIN
UNCLASSIFIED DRUG
UREA
URIC ACID
VASCULOTROPIN
ANIMAL EXPERIMENT
ANIMAL MODEL
ANIMAL TISSUE
ARTICLE
BLOOD FLOW
BODY MASS
BRAIN MASS
BRONCHOALVEOLAR LAVAGE FLUID
CELL COUNT
CONTROLLED STUDY
DIASTOLIC BLOOD PRESSURE
DNA FRAGMENTATION
ELECTROCARDIOGRAPHY
ERYTHROCYTE COUNT
EXPOSURE
FEMALE
HEART MASS
HEART RATE
HEMATOCRIT
HYPERTENSION
LEAD POISONING
LIVER MASS
LUNG MASS
MEAN CORPUSCULAR HEMOGLOBIN
MEAN CORPUSCULAR VOLUME
MEAN PLATELET VOLUME
NEUTROPHIL
NONHUMAN
PARTICLE SIZE
RAT
SCANNING ELECTRON MICROSCOPY
SPLEEN SIZE
SYSTOLIC BLOOD PRESSURE
TOXICITY
TRANSMISSION ELECTRON MICROSCOPY
URINARY EXCRETION
URI: http://hdl.handle.net/10995/90450
https://elar.urfu.ru/handle/10995/90450
metadata.dc.rights: info:eu-repo/semantics/openAccess
cc-by
SCOPUS ID: 85078263640
WOS ID: 000522551600004
PURE ID: 11996370
ISSN: 1661-6596
DOI: 10.3390/ijms21030690
metadata.dc.description.sponsorship: Funding: This work was funded by the budget of the Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers.
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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