Comparison of Depolarization and Depolarization in Mathematical Models of the Left Ventricle and the Longitudinal Ventricular Slice

Abstract

Myocardial slices are widely used for cardiac electrophysiology research but correspondence of electrophysiological properties between the cardiac slices and the whole heart has not been studied in details. The aim of this study is to investigate the differences in electrophysiological properties between the left ventricle and the longitudinal ventricular slice passing through the apex using mathematical models. ECG signals and the time of activation and repolarization, repolarization dispersion and dispersion of action potential duration were compared. We have shown that the electrophysiological processes in the ventricle and the longitudinal ventricular slice are quite similar, so we believe that cardiac slices can be used to evaluate global electrophysiological properties of the ventricles. The local differences obtained can be explained by differences in geometry and fiber orientation locally affecting depolarization and repolarization in the myocardium. © 2018 Creative Commons Attribution.