Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/75630
Title: Dynamical anchoring of distant arrhythmia sources by fibrotic regions via restructuring of the activation pattern
Authors: Vandersickel, N.
Watanabe, M.
Tao, Q.
Fostier, J.
Zeppenfeld, K.
Panfilov, A. V.
Issue Date: 2018
Publisher: Public Library of Science
Citation: Dynamical anchoring of distant arrhythmia sources by fibrotic regions via restructuring of the activation pattern / N. Vandersickel, M. Watanabe, Q. Tao et al. // PLoS Computational Biology. — 2018. — Vol. 14. — Iss. 12. — e1006637.
Abstract: Rotors are functional reentry sources identified in clinically relevant cardiac arrhythmias, such as ventricular and atrial fibrillation. Ablation targeting rotor sites has resulted in arrhythmia termination. Recent clinical, experimental and modelling studies demonstrate that rotors are often anchored around fibrotic scars or regions with increased fibrosis. However the mechanisms leading to abundance of rotors at these locations are not clear. The current study explores the hypothesis whether fibrotic scars just serve as anchoring sites for the rotors or whether there are other active processes which drive the rotors to these fibrotic regions. Rotors were induced at different distances from fibrotic scars of various sizes and degree of fibrosis. Simulations were performed in a 2D model of human ventricular tissue and in a patient-specific model of the left ventricle of a patient with remote myocardial infarction. In both the 2D and the patient-specific model we found that without fibrotic scars, the rotors were stable at the site of their initiation. However, in the presence of a scar, rotors were eventually dynamically anchored from large distances by the fibrotic scar via a process of dynamical reorganization of the excitation pattern. This process coalesces with a change from polymorphic to monomorphic ventricular tachycardia. © 2018 Vandersickel et al. http://creativecommons.org/licenses/by/4.0/.
Keywords: ARTICLE
CLINICAL ARTICLE
COMPUTER MODEL
COMPUTER SIMULATION
CONTROLLED STUDY
DYNAMICS
ELECTROCARDIOGRAPHY
HEART ARRHYTHMIA
HEART INFARCTION
HEART LEFT VENTRICLE
HEART MUSCLE FIBROSIS
HEART VENTRICLE TACHYCARDIA
HUMAN
MONOMORHPIC VENTRICULAR TACHYCARDIA
POLYMORPHIC VENTRICULAR TACHYCARDIA
QRS COMPLEX
ROTOR DYNAMICS
ACTION POTENTIAL
BIOLOGICAL MODEL
BIOLOGY
CATHETER ABLATION
ELECTROPHYSIOLOGY
FIBROSIS
HEART ARRHYTHMIA
HEART MUSCLE CONDUCTION SYSTEM
HEART VENTRICLE
NUCLEAR MAGNETIC RESONANCE IMAGING
PATHOLOGY
PATHOPHYSIOLOGY
ACTION POTENTIALS
ARRHYTHMIAS, CARDIAC
CATHETER ABLATION
COMPUTATIONAL BIOLOGY
COMPUTER SIMULATION
ELECTROCARDIOGRAPHY
ELECTROPHYSIOLOGICAL PHENOMENA
FIBROSIS
HEART CONDUCTION SYSTEM
HEART VENTRICLES
HUMANS
MAGNETIC RESONANCE IMAGING
MODELS, CARDIOVASCULAR
MYOCARDIAL INFARCTION
URI: http://hdl.handle.net/10995/75630
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85059499920
WOS ID: 000454835100035
PURE ID: 8547543
ISSN: 1553-734X
DOI: 10.1371/journal.pcbi.1006637
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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