Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на этот ресурс: http://elar.urfu.ru/handle/10995/75630
Полная запись метаданных
Поле DCЗначениеЯзык
dc.contributor.authorVandersickel, N.en
dc.contributor.authorWatanabe, M.en
dc.contributor.authorTao, Q.en
dc.contributor.authorFostier, J.en
dc.contributor.authorZeppenfeld, K.en
dc.contributor.authorPanfilov, A. V.en
dc.date.accessioned2019-07-22T06:48:04Z-
dc.date.available2019-07-22T06:48:04Z-
dc.date.issued2018-
dc.identifier.citationDynamical anchoring of distant arrhythmia sources by fibrotic regions via restructuring of the activation pattern / N. Vandersickel, M. Watanabe, Q. Tao et al. // PLoS Computational Biology. — 2018. — Vol. 14. — Iss. 12. — e1006637.en
dc.identifier.issn1553-734X-
dc.identifier.otherhttps://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006637&type=printablepdf
dc.identifier.other1good_DOI
dc.identifier.other05ade366-8bce-46ee-b130-66462d297dbepure_uuid
dc.identifier.otherhttp://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85059499920m
dc.identifier.urihttp://elar.urfu.ru/handle/10995/75630-
dc.description.abstractRotors are functional reentry sources identified in clinically relevant cardiac arrhythmias, such as ventricular and atrial fibrillation. Ablation targeting rotor sites has resulted in arrhythmia termination. Recent clinical, experimental and modelling studies demonstrate that rotors are often anchored around fibrotic scars or regions with increased fibrosis. However the mechanisms leading to abundance of rotors at these locations are not clear. The current study explores the hypothesis whether fibrotic scars just serve as anchoring sites for the rotors or whether there are other active processes which drive the rotors to these fibrotic regions. Rotors were induced at different distances from fibrotic scars of various sizes and degree of fibrosis. Simulations were performed in a 2D model of human ventricular tissue and in a patient-specific model of the left ventricle of a patient with remote myocardial infarction. In both the 2D and the patient-specific model we found that without fibrotic scars, the rotors were stable at the site of their initiation. However, in the presence of a scar, rotors were eventually dynamically anchored from large distances by the fibrotic scar via a process of dynamical reorganization of the excitation pattern. This process coalesces with a change from polymorphic to monomorphic ventricular tachycardia. © 2018 Vandersickel et al. http://creativecommons.org/licenses/by/4.0/.en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.sourcePLoS Computational Biologyen
dc.subjectARTICLEen
dc.subjectCLINICAL ARTICLEen
dc.subjectCOMPUTER MODELen
dc.subjectCOMPUTER SIMULATIONen
dc.subjectCONTROLLED STUDYen
dc.subjectDYNAMICSen
dc.subjectELECTROCARDIOGRAPHYen
dc.subjectHEART ARRHYTHMIAen
dc.subjectHEART INFARCTIONen
dc.subjectHEART LEFT VENTRICLEen
dc.subjectHEART MUSCLE FIBROSISen
dc.subjectHEART VENTRICLE TACHYCARDIAen
dc.subjectHUMANen
dc.subjectMONOMORHPIC VENTRICULAR TACHYCARDIAen
dc.subjectPOLYMORPHIC VENTRICULAR TACHYCARDIAen
dc.subjectQRS COMPLEXen
dc.subjectROTOR DYNAMICSen
dc.subjectACTION POTENTIALen
dc.subjectBIOLOGICAL MODELen
dc.subjectBIOLOGYen
dc.subjectCATHETER ABLATIONen
dc.subjectELECTROPHYSIOLOGYen
dc.subjectFIBROSISen
dc.subjectHEART ARRHYTHMIAen
dc.subjectHEART MUSCLE CONDUCTION SYSTEMen
dc.subjectHEART VENTRICLEen
dc.subjectNUCLEAR MAGNETIC RESONANCE IMAGINGen
dc.subjectPATHOLOGYen
dc.subjectPATHOPHYSIOLOGYen
dc.subjectACTION POTENTIALSen
dc.subjectARRHYTHMIAS, CARDIACen
dc.subjectCATHETER ABLATIONen
dc.subjectCOMPUTATIONAL BIOLOGYen
dc.subjectCOMPUTER SIMULATIONen
dc.subjectELECTROCARDIOGRAPHYen
dc.subjectELECTROPHYSIOLOGICAL PHENOMENAen
dc.subjectFIBROSISen
dc.subjectHEART CONDUCTION SYSTEMen
dc.subjectHEART VENTRICLESen
dc.subjectHUMANSen
dc.subjectMAGNETIC RESONANCE IMAGINGen
dc.subjectMODELS, CARDIOVASCULARen
dc.subjectMYOCARDIAL INFARCTIONen
dc.titleDynamical anchoring of distant arrhythmia sources by fibrotic regions via restructuring of the activation patternen
dc.typeArticleen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeinfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.1371/journal.pcbi.1006637-
dc.identifier.scopus85059499920-
local.affiliationDepartment of Physics and Astronomy, Ghent University, Belgiumen
local.affiliationDepartment of Cardiology, Leiden University Medical Center, Leiden, Netherlandsen
local.affiliationDepartment of Radiology, Division of Image Processing, Leiden University Medical Centre, Leiden, Netherlandsen
local.affiliationDepartment of Information Technology (INTEC), IDLab Ghent University — imec, Ghent, Belgiumen
local.affiliationLaboratory of Computational Biology and Medicine, Ural Federal University, Ekaterinburg, Russian Federationen
local.contributor.employeeПанфилов Александр Викторовичru
local.issue12-
local.volume14-
dc.identifier.wos000454835100035-
local.identifier.pure8547543-
local.description.ordere1006637-
local.identifier.eid2-s2.0-85059499920-
local.identifier.wosWOS:000454835100035-
Располагается в коллекциях:Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

Файлы этого ресурса:
Файл Описание РазмерФормат 
10.1371-journal.pcbi.1006637.pdf1,75 MBAdobe PDFПросмотреть/Открыть


Все ресурсы в архиве электронных ресурсов защищены авторским правом, все права сохранены.