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Поле DC | Значение | Язык |
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dc.contributor.author | Vandersickel, N. | en |
dc.contributor.author | Watanabe, M. | en |
dc.contributor.author | Tao, Q. | en |
dc.contributor.author | Fostier, J. | en |
dc.contributor.author | Zeppenfeld, K. | en |
dc.contributor.author | Panfilov, A. V. | en |
dc.date.accessioned | 2019-07-22T06:48:04Z | - |
dc.date.available | 2019-07-22T06:48:04Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Dynamical anchoring of distant arrhythmia sources by fibrotic regions via restructuring of the activation pattern / N. Vandersickel, M. Watanabe, Q. Tao et al. // PLoS Computational Biology. — 2018. — Vol. 14. — Iss. 12. — e1006637. | en |
dc.identifier.issn | 1553-734X | - |
dc.identifier.other | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006637&type=printable | |
dc.identifier.other | 1 | good_DOI |
dc.identifier.other | 05ade366-8bce-46ee-b130-66462d297dbe | pure_uuid |
dc.identifier.other | http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85059499920 | m |
dc.identifier.uri | http://elar.urfu.ru/handle/10995/75630 | - |
dc.description.abstract | Rotors are functional reentry sources identified in clinically relevant cardiac arrhythmias, such as ventricular and atrial fibrillation. Ablation targeting rotor sites has resulted in arrhythmia termination. Recent clinical, experimental and modelling studies demonstrate that rotors are often anchored around fibrotic scars or regions with increased fibrosis. However the mechanisms leading to abundance of rotors at these locations are not clear. The current study explores the hypothesis whether fibrotic scars just serve as anchoring sites for the rotors or whether there are other active processes which drive the rotors to these fibrotic regions. Rotors were induced at different distances from fibrotic scars of various sizes and degree of fibrosis. Simulations were performed in a 2D model of human ventricular tissue and in a patient-specific model of the left ventricle of a patient with remote myocardial infarction. In both the 2D and the patient-specific model we found that without fibrotic scars, the rotors were stable at the site of their initiation. However, in the presence of a scar, rotors were eventually dynamically anchored from large distances by the fibrotic scar via a process of dynamical reorganization of the excitation pattern. This process coalesces with a change from polymorphic to monomorphic ventricular tachycardia. © 2018 Vandersickel et al. http://creativecommons.org/licenses/by/4.0/. | en |
dc.format.mimetype | application/pdf | en |
dc.language.iso | en | en |
dc.publisher | Public Library of Science | en |
dc.rights | info:eu-repo/semantics/openAccess | en |
dc.source | PLoS Computational Biology | en |
dc.subject | ARTICLE | en |
dc.subject | CLINICAL ARTICLE | en |
dc.subject | COMPUTER MODEL | en |
dc.subject | COMPUTER SIMULATION | en |
dc.subject | CONTROLLED STUDY | en |
dc.subject | DYNAMICS | en |
dc.subject | ELECTROCARDIOGRAPHY | en |
dc.subject | HEART ARRHYTHMIA | en |
dc.subject | HEART INFARCTION | en |
dc.subject | HEART LEFT VENTRICLE | en |
dc.subject | HEART MUSCLE FIBROSIS | en |
dc.subject | HEART VENTRICLE TACHYCARDIA | en |
dc.subject | HUMAN | en |
dc.subject | MONOMORHPIC VENTRICULAR TACHYCARDIA | en |
dc.subject | POLYMORPHIC VENTRICULAR TACHYCARDIA | en |
dc.subject | QRS COMPLEX | en |
dc.subject | ROTOR DYNAMICS | en |
dc.subject | ACTION POTENTIAL | en |
dc.subject | BIOLOGICAL MODEL | en |
dc.subject | BIOLOGY | en |
dc.subject | CATHETER ABLATION | en |
dc.subject | ELECTROPHYSIOLOGY | en |
dc.subject | FIBROSIS | en |
dc.subject | HEART ARRHYTHMIA | en |
dc.subject | HEART MUSCLE CONDUCTION SYSTEM | en |
dc.subject | HEART VENTRICLE | en |
dc.subject | NUCLEAR MAGNETIC RESONANCE IMAGING | en |
dc.subject | PATHOLOGY | en |
dc.subject | PATHOPHYSIOLOGY | en |
dc.subject | ACTION POTENTIALS | en |
dc.subject | ARRHYTHMIAS, CARDIAC | en |
dc.subject | CATHETER ABLATION | en |
dc.subject | COMPUTATIONAL BIOLOGY | en |
dc.subject | COMPUTER SIMULATION | en |
dc.subject | ELECTROCARDIOGRAPHY | en |
dc.subject | ELECTROPHYSIOLOGICAL PHENOMENA | en |
dc.subject | FIBROSIS | en |
dc.subject | HEART CONDUCTION SYSTEM | en |
dc.subject | HEART VENTRICLES | en |
dc.subject | HUMANS | en |
dc.subject | MAGNETIC RESONANCE IMAGING | en |
dc.subject | MODELS, CARDIOVASCULAR | en |
dc.subject | MYOCARDIAL INFARCTION | en |
dc.title | Dynamical anchoring of distant arrhythmia sources by fibrotic regions via restructuring of the activation pattern | en |
dc.type | Article | en |
dc.type | info:eu-repo/semantics/article | en |
dc.type | info:eu-repo/semantics/publishedVersion | en |
dc.identifier.doi | 10.1371/journal.pcbi.1006637 | - |
dc.identifier.scopus | 85059499920 | - |
local.affiliation | Department of Physics and Astronomy, Ghent University, Belgium | en |
local.affiliation | Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands | en |
local.affiliation | Department of Radiology, Division of Image Processing, Leiden University Medical Centre, Leiden, Netherlands | en |
local.affiliation | Department of Information Technology (INTEC), IDLab Ghent University — imec, Ghent, Belgium | en |
local.affiliation | Laboratory of Computational Biology and Medicine, Ural Federal University, Ekaterinburg, Russian Federation | en |
local.contributor.employee | Панфилов Александр Викторович | ru |
local.issue | 12 | - |
local.volume | 14 | - |
dc.identifier.wos | 000454835100035 | - |
local.identifier.pure | 8547543 | - |
local.description.order | e1006637 | - |
local.identifier.eid | 2-s2.0-85059499920 | - |
local.identifier.wos | WOS:000454835100035 | - |
Располагается в коллекциях: | Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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10.1371-journal.pcbi.1006637.pdf | 1,75 MB | Adobe PDF | Просмотреть/Открыть |
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