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Title: | One-pot, three-component synthesis of 7-azaindole derivatives from N-substituted 2-amino-4-cyanopyrroles, various aldehydes, and active methylene compounds |
Authors: | Vilches-Herrera, Marcelo Knepper, Ingo De Souza, Nayane Villinger, Alexander Sosnovskikh, Vyacheslav Ya. Iaroshenko, Viktor O. |
Issue Date: | 2012 |
Citation: | One-pot, three-component synthesis of 7-azaindole derivatives from N-substituted 2-amino-4-cyanopyrroles, various aldehydes, and active methylene compounds / Marcelo Vilches-Herrera, Ingo Knepper, Nayane De Souza, Alexander Villinger, Vyacheslav Ya. Sosnovskikh, Viktor O. Iaroshenko // ACS Combinatorial Science. — 2012. — Vol. 14. — № 7. — P. 434-441. |
Abstract: | An efficient and practical route to 7-azaindole framework has been developed by one-pot, three-component cyclocondensation of N-substituted 2-amino-4-cyanopyrroles, various aldehydes, and active methylene compounds in ethanol or acetic acid at reflux. Reactions involving tetronic acid, indane-1,3-dione, dimedone, and 5-phenylcyclohexane-1,3-dione gave carbocyclic fused 7-azaindoles, whereas Meldrum's acid, benzoylacetonitrile, and malononitrile resulted in the highly substituted 7-azaindole derivatives, making this strategy very useful in diversity-oriented synthesis (DOS). © 2012 American Chemical Society. |
Keywords: | 2-AMINOPYRROLES 7-AZAINDOLES ACTIVE METHYLENE COMPOUNDS AROMATIC ALDEHYDES HETEROCYCLISATION MULTICOMPONENT REACTION |
URI: | http://elar.urfu.ru/handle/10995/51127 |
SCOPUS ID: | 84863745523 |
WOS ID: | 000306149100007 |
PURE ID: | 1078819 |
ISSN: | 2156-8952 2156-8944 |
DOI: | 10.1021/co300042v |
Appears in Collections: | Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC |
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