Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/51127
Title: One-pot, three-component synthesis of 7-azaindole derivatives from N-substituted 2-amino-4-cyanopyrroles, various aldehydes, and active methylene compounds
Authors: Vilches-Herrera, Marcelo
Knepper, Ingo
De Souza, Nayane
Villinger, Alexander
Sosnovskikh, Vyacheslav Ya.
Iaroshenko, Viktor O.
Issue Date: 2012
Citation: One-pot, three-component synthesis of 7-azaindole derivatives from N-substituted 2-amino-4-cyanopyrroles, various aldehydes, and active methylene compounds / Marcelo Vilches-Herrera, Ingo Knepper, Nayane De Souza, Alexander Villinger, Vyacheslav Ya. Sosnovskikh, Viktor O. Iaroshenko // ACS Combinatorial Science. — 2012. — Vol. 14. — № 7. — P. 434-441.
Abstract: An efficient and practical route to 7-azaindole framework has been developed by one-pot, three-component cyclocondensation of N-substituted 2-amino-4-cyanopyrroles, various aldehydes, and active methylene compounds in ethanol or acetic acid at reflux. Reactions involving tetronic acid, indane-1,3-dione, dimedone, and 5-phenylcyclohexane-1,3-dione gave carbocyclic fused 7-azaindoles, whereas Meldrum's acid, benzoylacetonitrile, and malononitrile resulted in the highly substituted 7-azaindole derivatives, making this strategy very useful in diversity-oriented synthesis (DOS). © 2012 American Chemical Society.
Keywords: 2-AMINOPYRROLES
7-AZAINDOLES
ACTIVE METHYLENE COMPOUNDS
AROMATIC ALDEHYDES
HETEROCYCLISATION
MULTICOMPONENT REACTION
URI: http://hdl.handle.net/10995/51127
https://elar.urfu.ru/handle/10995/51127
SCOPUS ID: 84863745523
WOS ID: 000306149100007
PURE ID: 1078819
ISSN: 2156-8952
2156-8944
DOI: 10.1021/co300042v
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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