Please use this identifier to cite or link to this item:
http://elar.urfu.ru/handle/10995/27564
Title: | Clusteron structure of tick-borne encephalitis virus populations |
Authors: | Kovalev, S. Y. Mukhacheva, T. A. |
Issue Date: | 2013 |
Citation: | Kovalev S. Y. Clusteron structure of tick-borne encephalitis virus populations / S. Y. Kovalev, T. A. Mukhacheva // Infection, Genetics and Evolution. — 2013. — Vol. 14. — № 1. — P. 22-28. |
Abstract: | Tick-borne encephalitis is a natural focal transmissible zooanthroponosis. The causative agent of the disease is a tick-borne encephalitis virus (TBEV) belonging to the genus Flavivirus of the family Flaviviridae and is widespread in Eurasia. Current TBEV classification based on molecular genetic data comprises three phylogenetically separate subtypes: Far Eastern, European and Siberian (TBEV-Sib). Further differentiation of TBEV isn't developed, making it difficult to investigate the origins, distribution and evolution of the virus. In the present study we determined the nucleotide sequence of the gene E fragment for 282 TBEV-Sib isolates from Ixodes persulcatus ticks or their pools from various natural foci in Russia. Analysis of these sequences and sequences obtained from the GenBank database (more than 600), made it possible to cluster TBEV-Sib strains by identical amino acid sequences of a glycoprotein E fragment. In total, 18 groups were identified (from 3 to 285 strains in the group). It was shown that TBEV strains belonging to the same group are phylogenetically related and have a territorial attachment showing either a local or a corridor type distribution. These groups were named as clusterons showed to be the smallest unit of TBEV classification. The grouping of TBEV strains allows characterization of endemic areas both in quantitative and qualitative composition of the clusterons. The approach could be successfully used to record and monitor the TBEV populations. © 2012 Elsevier B.V. |
Keywords: | CLASSIFICATION CLUSTERON EVOLUTION PHYLOGEOGRAPHY POPULATION TICK-BORNE ENCEPHALITIS VIRUS GLYCOPROTEIN E ARTICLE CLUSTERON IXODES PERSULCATUS NONHUMAN NUCLEOTIDE SEQUENCE PHYLOGENY PRIORITY JOURNAL SEQUENCE ANALYSIS SEQUENCE DATABASE STRAIN IDENTIFICATION TERRITORIALITY TICK BORNE ENCEPHALITIS FLAVIVIRUS VIRUS ATTACHMENT VIRUS CLASSIFICATION VIRUS GENE VIRUS ISOLATION VIRUS MORPHOLOGY VIRUS STRAIN VIRUS TYPING AMINO ACID SUBSTITUTION ANIMALS ENCEPHALITIS VIRUSES, TICK-BORNE ENCEPHALITIS, TICK-BORNE IXODES MODELS, MOLECULAR MOLECULAR SEQUENCE DATA PHYLOGENY PHYLOGEOGRAPHY RUSSIA VIRAL ENVELOPE PROTEINS FLAVIVIRIDAE FLAVIVIRUS IXODES PERSULCATUS IXODIDA TICK-BORNE ENCEPHALITIS VIRUS |
URI: | http://elar.urfu.ru/handle/10995/27564 |
SCOPUS ID: | 84871750232 |
WOS ID: | 000316841800004 |
PURE ID: | 912476 |
ISSN: | 1567-1348 |
DOI: | 10.1016/j.meegid.2012.10.011 |
Appears in Collections: | Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
scopus-2013-0185.pdf | 795,14 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.