Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/27564
Title: Clusteron structure of tick-borne encephalitis virus populations
Authors: Kovalev, S. Y.
Mukhacheva, T. A.
Issue Date: 2013
Citation: Kovalev S. Y. Clusteron structure of tick-borne encephalitis virus populations / S. Y. Kovalev, T. A. Mukhacheva // Infection, Genetics and Evolution. — 2013. — Vol. 14. — № 1. — P. 22-28.
Abstract: Tick-borne encephalitis is a natural focal transmissible zooanthroponosis. The causative agent of the disease is a tick-borne encephalitis virus (TBEV) belonging to the genus Flavivirus of the family Flaviviridae and is widespread in Eurasia. Current TBEV classification based on molecular genetic data comprises three phylogenetically separate subtypes: Far Eastern, European and Siberian (TBEV-Sib). Further differentiation of TBEV isn't developed, making it difficult to investigate the origins, distribution and evolution of the virus. In the present study we determined the nucleotide sequence of the gene E fragment for 282 TBEV-Sib isolates from Ixodes persulcatus ticks or their pools from various natural foci in Russia. Analysis of these sequences and sequences obtained from the GenBank database (more than 600), made it possible to cluster TBEV-Sib strains by identical amino acid sequences of a glycoprotein E fragment. In total, 18 groups were identified (from 3 to 285 strains in the group). It was shown that TBEV strains belonging to the same group are phylogenetically related and have a territorial attachment showing either a local or a corridor type distribution. These groups were named as clusterons showed to be the smallest unit of TBEV classification. The grouping of TBEV strains allows characterization of endemic areas both in quantitative and qualitative composition of the clusterons. The approach could be successfully used to record and monitor the TBEV populations. © 2012 Elsevier B.V.
Keywords: CLASSIFICATION
CLUSTERON
EVOLUTION
PHYLOGEOGRAPHY
POPULATION
TICK-BORNE ENCEPHALITIS VIRUS
GLYCOPROTEIN E
ARTICLE
CLUSTERON
IXODES PERSULCATUS
NONHUMAN
NUCLEOTIDE SEQUENCE
PHYLOGENY
PRIORITY JOURNAL
SEQUENCE ANALYSIS
SEQUENCE DATABASE
STRAIN IDENTIFICATION
TERRITORIALITY
TICK BORNE ENCEPHALITIS FLAVIVIRUS
VIRUS ATTACHMENT
VIRUS CLASSIFICATION
VIRUS GENE
VIRUS ISOLATION
VIRUS MORPHOLOGY
VIRUS STRAIN
VIRUS TYPING
AMINO ACID SUBSTITUTION
ANIMALS
ENCEPHALITIS VIRUSES, TICK-BORNE
ENCEPHALITIS, TICK-BORNE
IXODES
MODELS, MOLECULAR
MOLECULAR SEQUENCE DATA
PHYLOGENY
PHYLOGEOGRAPHY
RUSSIA
VIRAL ENVELOPE PROTEINS
FLAVIVIRIDAE
FLAVIVIRUS
IXODES PERSULCATUS
IXODIDA
TICK-BORNE ENCEPHALITIS VIRUS
URI: http://hdl.handle.net/10995/27564
SCOPUS ID: 84871750232
WOS ID: 000316841800004
PURE ID: 912476
ISSN: 1567-1348
DOI: 10.1016/j.meegid.2012.10.011
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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