A novel, two-step synthesis of 4-pyridone-3-carboxamides from 2-cyano-4-pyrones

Please use this identifier to cite or link to this item: http://elar.urfu.ru/handle/10995/27071

Title:	A novel, two-step synthesis of 4-pyridone-3-carboxamides from 2-cyano-4-pyrones
Authors:	Obydennov, D. L. Sidorova, E. S. Usachev, B. I. Sosnovskikh, V. Y.
Issue Date:	2013
Citation:	A novel, two-step synthesis of 4-pyridone-3-carboxamides from 2-cyano-4-pyrones / D. L. Obydennov, E. S. Sidorova, B. I. Usachev [et al.] // Tetrahedron Letters. — 2013. — Vol. 54. — № 24. — P. 3085-3087.
Abstract:	Reactions of 2-cyano-6-(trifluoromethyl)-4-pyrone, 2-cyano-4-pyrone, and 2-cyano-6-methyl-4-pyrone with aliphatic and aromatic amines in ethanol at -20 C for 2-21 days gave 5-amino-3-oxopent-4-enamides in 28-78% yields, which were cyclized with DMF-DMA in toluene under ambient conditions to afford 4-pyridone-3-carboxamides in 31-70% yields. © 2013 Elsevier Ltd. All rights reserved.
Keywords:	2-CYANO-4-PYRONES 4-PYRIDONE-3-CARBOXAMIDES 5-AMINO-3-OXOPENT-4-ENAMIDES CYCLIZATION DMF-DMA 2 CYANO 4 PYRONE 2 CYANO 6 (TRIFLUOROMETHYL) 4 PYRONE 2 CYANO 6 METHYL 4 PYRONE 4 OXO 6 (TRIFLUOROMETHYL) 4H PYRAN 2 CARBOXAMIDE 4 PYRIDONE 3 CARBOXAMIDE DERIVATIVE ALCOHOL AMIDE PYRONE DERIVATIVE TOLUENE UNCLASSIFIED DRUG ARTICLE CHEMICAL REACTION SYNTHESIS TEMPERATURE MEASUREMENT
URI:	http://elar.urfu.ru/handle/10995/27071
SCOPUS ID:	84877689437
WOS ID:	000319645100014
PURE ID:	902841
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2013.03.132
Appears in Collections:	Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

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