High lactic acid levels in the brain contribute to the generation of focal slowing on the electroencephalogram

Chegodaev, D. A.; Pavlova, P. A.

doi:10.3389/fneur.2024.1393274

Please use this identifier to cite or link to this item: http://elar.urfu.ru/handle/10995/141555

Title:	High lactic acid levels in the brain contribute to the generation of focal slowing on the electroencephalogram
Authors:	Chegodaev, D. A. Pavlova, P. A.
Issue Date:	2024
Publisher:	Frontiers Media SA
Citation:	Chegodaev, D., & Pavlova, P. (2024). High lactic acid levels in the brain contribute to the generation of focal slowing on the electroencephalogram. Frontiers in Neurology, 15, [1393274]. https://doi.org/10.3389/fneur.2024.1393274
Abstract:	Focal slowing on the EEG is often associated with structural pathology of the brain. Despite the clinical significance of focal slowing, the actual electrochemical mechanisms underlying this EEG phenomenon are still poorly understood. This paper briefly reviews the role of lactate in the pathogenesis of brain disorders that are primarily related to focal EEG slowing. An attempt is made to trace the hypothetical link between this EEG pattern and focal cerebral tissue lactacidosis. Copyright © 2024 Chegodaev and Pavlova.
Keywords:	ACIDOSIS ELECTROENCEPHALOGRAM EPILEPSY FOCAL SLOWING LACTATE STRUCTURAL LESIONS ADENOSINE TRIPHOSPHATE ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL CONNEXIN 43 CREATINE KINASE CYSTINE GLUCOSE TRANSPORTER 4 GLUTAMATE AMMONIA LIGASE GLUTAMIC ACID GLYCINE K RAS PROTEIN LACTIC ACID MITOGEN ACTIVATED PROTEIN KINASE 3 N METHYL DEXTRO ASPARTIC ACID RECEPTOR SODIUM CHANNEL NAV1.5 AEROBIC GLYCOLYSIS ASTROCYTOSIS BRAIN DISEASE BRAIN ISCHEMIA BRAIN METABOLISM BRAIN TISSUE CLINICAL SIGNIFICANCE ELECTROENCEPHALOGRAM ELECTROPHYSIOLOGY GLUCOSE TRANSPORT GLYCOLYSIS HEART VENTRICLE ARRHYTHMIA HUMAN HYPERPOLARIZATION KETOGENIC DIET LACTIC ACIDOSIS MENINGIOMA OXIDATIVE PHOSPHORYLATION PATHOGENESIS PROTEIN EXPRESSION PROTEIN PHOSPHORYLATION RESPIRATORY CHAIN SEIZURE SHORT SURVEY SHORT SURVEY SIGNAL TRANSDUCTION TUMOR GROWTH TUMOR MICROENVIRONMENT
URI:	http://elar.urfu.ru/handle/10995/141555
Access:	info:eu-repo/semantics/openAccess cc-by
SCOPUS ID:	85191809278
WOS ID:	001209833900001
PURE ID:	56648947
ISSN:	1664-2295
DOI:	10.3389/fneur.2024.1393274
Sponsorship:	Russian Science Foundation, RSF, (24-28-01671); Russian Science Foundation, RSF The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work has been supported by the grants \u201Cthe Russian Science Foundation,\u201D RSF No 24-28-01671, https://rscf.ru/en/project/24-28-01671/.
RSCF project card:	24-28-01671
Appears in Collections:	Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

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