Nucleophilic substitution of nitro group in nitrotriazolotriazines as a model of potential interaction with cysteine-containing proteins

Rusinov, V. L.; Sapozhnikova, I. M.; Ulomskii, E. N.; Medvedeva, N. R.; Egorov, V. V.; Kiselev, O. I.; Deeva, E. G.; Vasin, A. V.; Chupakhin, O. N.

doi:10.1007/s10593-015-1695-4

Please use this identifier to cite or link to this item: http://elar.urfu.ru/handle/10995/132506

Title:	Nucleophilic substitution of nitro group in nitrotriazolotriazines as a model of potential interaction with cysteine-containing proteins
Authors:	Rusinov, V. L. Sapozhnikova, I. M. Ulomskii, E. N. Medvedeva, N. R. Egorov, V. V. Kiselev, O. I. Deeva, E. G. Vasin, A. V. Chupakhin, O. N.
Issue Date:	2015
Publisher:	Springer New York LLC
Citation:	Rusinov, V. L. et al. (2015) ‘Nucleophilic substitution of nitro group in nitrotriazolotriazines as a model of potential interaction with cysteine-containing proteins’, Chemistry of heterocyclic compounds. Springer Science and Business Media LLC, 51(3), pp. 275–280. doi: 10.1007/s10593-015-1695-4. Rusinov, V. L., Sapozhnikova, I. M., Ulomskii, E. N., Medvedeva, N. R., Egorov, V. V., Kiselev, O. I., … Chupakhin, O. N. (2015). Nucleophilic substitution of nitro group in nitrotriazolotriazines as a model of potential interaction with cysteine-containing proteins. Chemistry of Heterocyclic Compounds, 51(3), 275–280. doi:10.1007/s10593-015-1695-4
Abstract:	[Figure not available: see fulltext.] The nucleophilic susbstitution of nitro group in [1,2,4]triazolo[5,1-c][1,2,4]triazinones upon treatment with cysteine and glutathione was studied as a model for the interaction with thiol groups of virus proteins, which mimics the metabolic transformations of antiviral drug Triazavirin® and its derivatives. © 2015 Springer Science+Business Media New York.
Keywords:	AZOLO[5,1-C]TRIAZINES CYSTEINE GLUTATHIONE METABOLIC TRANSFORMATIONS NITRO COMPOUNDS NUCLEOPHILIC SUBSTITUTION TRIAZAVIRIN
URI:	http://elar.urfu.ru/handle/10995/132506
Access:	info:eu-repo/semantics/openAccess
SCOPUS ID:	84953354086
WOS ID:	000354479700011
PURE ID:	397477
ISSN:	0009-3122
DOI:	10.1007/s10593-015-1695-4
Sponsorship:	Russian Science Foundation, RSF: 14-13-01301 The study was performed with the financial support from the Russian Science Foundation (grant 14-13-01301).
RSCF project card:	14-13-01301
Appears in Collections:	Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

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