Please use this identifier to cite or link to this item: http://elar.urfu.ru/handle/10995/130669
Title: Pharmacological Potential of Betulin as a Multitarget Compound
Authors: Adepoju, F. O.
Duru, K. C.
Li, E.
Kovaleva, E. G.
Tsurkan, M. V.
Issue Date: 2023
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
Citation: Adepoju, FO, Duru, KC, Li, E, Kovaleva, EG & Tsurkan, MV 2023, 'Pharmacological Potential of Betulin as a Multitarget Compound', Biomolecules, Том. 13, № 7, 1105. https://doi.org/10.3390/biom13071105
Adepoju, F. O., Duru, K. C., Li, E., Kovaleva, E. G., & Tsurkan, M. V. (2023). Pharmacological Potential of Betulin as a Multitarget Compound. Biomolecules, 13(7), [1105]. https://doi.org/10.3390/biom13071105
Abstract: Betulin is a natural triterpene, usually from birch bark, known for its potential wound-healing properties. Despite having a wide range of pharmacological targets, no studies have proposed betulin as a multitarget compound. Betulin has protective effects against cardiovascular and liver diseases, cancer, diabetes, oxidative stress, and inflammation. It reduces postprandial hyperglycemia by inhibiting α-amylase and α-glucosidase activity, combats tumor cells by inducing apoptosis and inhibiting metastatic proteins, and modulates chronic inflammation by blocking the expression of proinflammatory cytokines via modulation of the NFκB and MAPKs pathways. Given its potential to influence diverse biological networks with high target specificity, it can be hypothesized that betulin may eventually become a new lead for drug development because it can modify a variety of pharmacological targets. The summarized research revealed that the diverse beneficial effects of betulin in various diseases can be attributed, at least in part, to its multitarget anti-inflammatory activity. This review focuses on the natural sources, pharmacokinetics, pharmacological activity of betulin, and the multi-target effects of betulin on signaling pathways such as MAPK, NF-κB, and Nrf2, which are important regulators of the response to oxidative stress and inflammation in the body. © 2023 by the authors.
Keywords: ANTI-INFLAMMATORY
BETULIN
HEPATOPROTECTIVE
INFLAMMATION
NATURAL PRODUCTS (MAPK, NRF2, NFΚB)
ABC TRANSPORTER A1
ABC TRANSPORTER G1
ADIPONECTIN
AGGRECAN
ALANINE AMINOTRANSFERASE
ALPHA GLUCOSIDASE
ALPHA SMOOTH MUSCLE ACTIN
AMYLASE
ASPARTATE AMINOTRANSFERASE
BETULIN
CASPASE 12
CASPASE 3
CASPASE 7
CASPASE 8
CASPASE 9
CD68 ANTIGEN
CISPLATIN
COLLAGEN TYPE 1
COLLAGEN TYPE 2
COLLAGENASE 3
CRYOPYRIN
CYTOCHROME P450 2E1
EPIDERMAL GROWTH FACTOR
FATTY ACID SYNTHASE
GAMMA INTERFERON
GELATINASE A
GLUTATHIONE
GLUTATHIONE PEROXIDASE
GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153
HEME OXYGENASE 1
HIGH MOBILITY GROUP B1 PROTEIN
HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE KINASE
IMMUNOGLOBULIN ENHANCER BINDING PROTEIN
INTERLEUKIN 12P35
INTERLEUKIN 12P70
INTERLEUKIN 17
INTERLEUKIN 1ALPHA
INTERLEUKIN 1BETA
INTERLEUKIN 1BETA CONVERTING ENZYME
MITOGEN ACTIVATED PROTEIN KINASE
MITOGEN ACTIVATED PROTEIN KINASE 1
MITOGEN ACTIVATED PROTEIN KINASE 3
OSTEOGENIC PROTEIN 1
PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA
PROSTAGLANDIN E2
PROTEIN BAX
PROTEIN BCL 2
PROTEIN P53
PURINERGIC P2X7 RECEPTOR
RANTES
SIRTUIN 1
STAT3 PROTEIN
STEROL REGULATORY ELEMENT BINDING PROTEIN 1
STEROL REGULATORY ELEMENT BINDING PROTEIN 1C
SYNAPTOPHYSIN
SYNAPTOTAGMIN I
TOLL LIKE RECEPTOR 4
TRANSCRIPTION FACTOR NRF2
TRANSFORMING GROWTH FACTOR BETA
TRIACYLGLYCEROL
TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
VASCULOTROPIN
X LINKED INHIBITOR OF APOPTOSIS
BETULIC ACID
BETULIN
CYTOKINE
IMMUNOGLOBULIN ENHANCER BINDING PROTEIN
TRITERPENE
786-O CELL LINE
A-549 CELL LINE
ACACIA AURICULIFORMIS
AKT SIGNALING
ALNUS GLUTINOSA
AML12 CELL LINE
ANEMONE RADDEANA
ANTIDIABETIC ACTIVITY
ANTIINFLAMMATORY ACTIVITY
APOPTOSIS
BALIOSPERMUM MONTANUM
BETULA PENDULA
BETULA PUBESCENS
CAKI-2 CELL LINE
CARDIOVASCULAR DISEASE
CELTIS SINENSIS
CROTON BONPLANDIANUS
DIABETES MELLITUS
DOLIOCARPUS DENTATUS
ENZYME ACTIVITY
EUPHORBIA HYSSOPIFOLIA
FOMES FOMENTARIUS
FTC-238 CELL LINE
H9C2(2-1) CELL LINE
HCT 116 CELL LINE
HEDYOTIS HEDYOTIDEA
HELA CELL LINE
HEP-G2 CELL LINE
HSC-T6 CELL LINE
HUMAN
HYGROPHILA AURICULATA
HYPERGLYCEMIA
IC50
INFLAMMATION
INONOTUS OBLIQUUS
LIGARIA CUNEIFOLIA
LIVER DISEASE
MATAYBA ELAEAGNOIDES
MCF-7 CELL LINE
MEDICINAL PLANT
MG-63 CELL LINE
NCI-H460 CELL LINE
NEOPLASM
NONHUMAN
OUGENIA DALBERGIOIDES
OVCAR-3 CELL LINE
OXIDATIVE STRESS
PAECILOMYCES
PC-3 [HUMAN PROSTATE CARCINOMA] CELL LINE
PLEUROSTYLIA CAPENSIS
PROTEIN EXPRESSION
PTERODON EMARGINATUS
PYROLA DECORATE
QUERCUS INCANA
RAW 264.7 CELL LINE
REVIEW
RHIZOPHORA MUCRONATA
SCHLEICHERA OLEOSA
SGC-7901 CELL LINE
SIGNAL TRANSDUCTION
SK-HEP-1 CELL LINE
T-47D CELL LINE
TE 671 CELL LINE
TECTONA GRANDIS
ULCERATIVE COLITIS
VACHELLIA NILOTICA
VISCUM COLORATUM
WOUND HEALING
XANTHIUM SIBIRICUM
INFLAMMATION
METABOLISM
BETULINIC ACID
CYTOKINES
HUMANS
INFLAMMATION
NF-KAPPA B
TRITERPENES
URI: http://elar.urfu.ru/handle/10995/130669
Access: info:eu-repo/semantics/openAccess
cc-by
License text: https://creativecommons.org/licenses/by/4.0/
SCOPUS ID: 85165972123
WOS ID: 001039224200001
PURE ID: 43280278
ISSN: 2218-273X
DOI: 10.3390/biom13071105
metadata.dc.description.sponsorship: Ministry of Education and Science of the Russian Federation, Minobrnauka: 075-15-2022-1118
This research was funded by the Ministry of Science and Higher Education of the Russian Federation MEGAGRANT, contract No 075-15-2022-1118, 29 June 2022.
Appears in Collections:Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

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