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http://elar.urfu.ru/handle/10995/111776
Название: | New Data on Variously Directed Dose-Response Relationships and the Combined Action Types for Different Outcomes of in Vitro Nanoparticle Cytotoxicity |
Авторы: | Panov, V. Bushueva, T. Minigalieva, I. Naumova, A. Shur, V. Shishkina, E. Sutunkova, M. Gurviсh, V. Privalova, L. Katsnelson, B. |
Дата публикации: | 2021 |
Издатель: | SAGE Publications Inc. SAGE Publications |
Библиографическое описание: | New Data on Variously Directed Dose-Response Relationships and the Combined Action Types for Different Outcomes of in Vitro Nanoparticle Cytotoxicity / V. Panov, T. Bushueva, I. Minigalieva et al. // Dose-Response. — 2021. — Vol. 19. — Iss. 4. — P. . |
Аннотация: | Spherical selenium-oxide and copper-oxide nanoparticles (SeO-NP with mean diameter 51 ± 14 nm and CuO-NP with mean diameter 21 ± 4 nm) were found to be cytotoxic for human fibroblast-like cells in vitro, as judged by decreased ATP-dependent luminescence. Compared with SeO-NP, CuO-NP produced a somewhat stronger effect of this kind. Along with cell hypertrophy developing in response to certain doses of SeO-NP and CuO-NP, our experiment also revealed doses causing a decrease in cell and cell-nucleus sizes. We observed both monotonic and different variants of nonmonotonic dose-response relationship. For the latter, we have succeeded in constructing adequate mathematical expressions based on the generalized hormesis paradigm that we had considered previously in respect of CdS-NP and PbS-NP cytotoxicity for cardiomyocites. It was demonstrated as well that combined toxicity of SeO-NP and CuO-NP is of different types depending on the outcome. © The Author(s) 2021. |
Ключевые слова: | COPPER-OXIDE DOSE-RESPONSE RELATIONSHIPS HORMESIS NANOPARTICLES SELENIUM-OXIDE COPPER OXIDE NANOPARTICLE SELENIUM OXIDE ARTICLE BIOLUMINESCENCE CELL CULTURE CYTOTOXICITY ENERGY DISPERSIVE X RAY SPECTROSCOPY HORMESIS IN VITRO STUDY |
URI: | http://elar.urfu.ru/handle/10995/111776 |
Условия доступа: | info:eu-repo/semantics/openAccess |
Идентификатор РИНЦ: | 47533692 |
Идентификатор SCOPUS: | 85120488201 |
Идентификатор WOS: | 000726751500001 |
Идентификатор PURE: | 29066484 |
ISSN: | 1559-3258 |
DOI: | 10.1177/15593258211052420 |
Сведения о поддержке: | The author(s) received no financial support for the research, authorship, and/or publication of this article. The equipment of the Ural Center for Shared Use "Modern nanotechnology" Ural Federal University (Reg.& numero; 2968) was used. |
Располагается в коллекциях: | Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC |
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Файл | Описание | Размер | Формат | |
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2-s2.0-85120488201.pdf | 1,05 MB | Adobe PDF | Просмотреть/Открыть |
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