Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/103347
Title: Transcriptomic Data Analyses Reveal a Reprogramed Lipid Metabolism in HCV-Derived Hepatocellular Cancer
Authors: Liu, G.
Liu, G.
Cui, X.
Xu, Y.
Issue Date: 2020
Publisher: Frontiers Media S.A.
Citation: Transcriptomic Data Analyses Reveal a Reprogramed Lipid Metabolism in HCV-Derived Hepatocellular Cancer / G. Liu, G. Liu, X. Cui, et al. — DOI 10.3389/fcell.2020.581863 // Frontiers in Cell and Developmental Biology. — 2020. — Vol. 8. — 581863.
Abstract: Reprograming lipid metabolism, one of the major metabolic alterations in cancer, is believed to play an essential role in cancer development, but the exact molecular mechanism remains elusive. Here, we present a computational study of transcriptomic data of HCC with HCV etiology to investigate how lipid metabolism alters during HCC progression. Our analyses reveal that: (1) cancer tissue cells tend to synthesize fatty acids de novo and its phospholipid derivatives; (2) lipid catabolism and fatty acid oxidation are remarkably down-regulated in HCC; (3) the lipid metabolism in HCC is largely independent of lipids in blood circulation; (4) stage-specific co-expression networks for lipid metabolic genes were identified during HCC progression; and (5) the expression levels of several lipid metabolic genes that are differentially expressed or co-expressed specifically at the HCC stage have a strong correlation with cancer survival. Overall, the results provide detailed information about the reprogramed lipid metabolism in HCV-derived HCC. © Copyright © 2020 Liu, Liu, Cui and Xu.
Keywords: DE NOVO SYNTHESIS OF FATTY ACID
GENE CO-EXPRESSION
GENE SET ENRICHMENT
HEPATOCELLULAR CANCER
LIPID METABOLISM
ACYL COENZYME A
AGPAT2 PROTEIN
APOL2 PROTEIN
APOL3 PROTEIN
APOLIPOPROTEIN
CHOLESTEROL ESTER TRANSFER PROTEIN
CYTOCHROME P450 1A2
CYTOCHROME P450 2A6
CYTOCHROME P450 2B6
CYTOCHROME P450 2C19
CYTOCHROME P450 2C8
FATTY ACID
FATTY ACID BINDING PROTEIN
GAMMA INTERFERON
LIPC PROTEIN
LIPG PROTEIN
LIPID
LONG CHAIN FATTY ACID
MGLL PROTEIN
NICOTINAMIDE ADENINE DINUCLEOTIDE
PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE
PHOSPHOLIPID DERIVATIVE
PPAP2B PROTEIN
PPAPDC1B PROTEIN
PROSTAGLANDIN A
TRIACYLGLYCEROL
UNCLASSIFIED DRUG
ARTICLE
CANCER GROWTH
CANCER SURVIVAL
CANCER TISSUE
CIRCULATION
CONTROLLED STUDY
DATA ANALYSIS
DOWN REGULATION
FATTY ACID OXIDATION
FATTY ACID SYNTHESIS
GENE EXPRESSION
GENE IDENTIFICATION
HEPATITIS C
HEPATITIS C VIRUS
HUMAN
HUMAN TISSUE
LIPID METABOLISM
LIPOLYSIS
LIVER CANCER
MAJOR CLINICAL STUDY
NUCLEAR REPROGRAMMING
PROTEIN EXPRESSION
TRANSCRIPTOMICS
URI: http://hdl.handle.net/10995/103347
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85095848053
PURE ID: 20132121
39fb31a3-11c3-4c85-83a4-00b21dc99b71
ISSN: 2296634X
DOI: 10.3389/fcell.2020.581863
metadata.dc.description.sponsorship: This work was supported by grants from the Inner Mongolia Natural Science Foundation of China (2018LH03023) and the Science Foundation for Excellent Youth Scholars of Inner Mongolia University of Science and Technology (2016YQL06).
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