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dc.contributor.authorLiu, G.en
dc.contributor.authorLiu, G.en
dc.contributor.authorCui, X.en
dc.contributor.authorXu, Y.en
dc.date.accessioned2021-08-31T15:09:08Z-
dc.date.available2021-08-31T15:09:08Z-
dc.date.issued2020-
dc.identifier.citationTranscriptomic Data Analyses Reveal a Reprogramed Lipid Metabolism in HCV-Derived Hepatocellular Cancer / G. Liu, G. Liu, X. Cui, et al. — DOI 10.3389/fcell.2020.581863 // Frontiers in Cell and Developmental Biology. — 2020. — Vol. 8. — 581863.en
dc.identifier.issn2296634X-
dc.identifier.otherFinal2
dc.identifier.otherAll Open Access, Gold, Green3
dc.identifier.otherhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85095848053&doi=10.3389%2ffcell.2020.581863&partnerID=40&md5=674b3bb622982db30126e545f6a33756
dc.identifier.otherhttps://www.frontiersin.org/articles/10.3389/fcell.2020.581863/pdfm
dc.identifier.urihttp://elar.urfu.ru/handle/10995/103347-
dc.description.abstractReprograming lipid metabolism, one of the major metabolic alterations in cancer, is believed to play an essential role in cancer development, but the exact molecular mechanism remains elusive. Here, we present a computational study of transcriptomic data of HCC with HCV etiology to investigate how lipid metabolism alters during HCC progression. Our analyses reveal that: (1) cancer tissue cells tend to synthesize fatty acids de novo and its phospholipid derivatives; (2) lipid catabolism and fatty acid oxidation are remarkably down-regulated in HCC; (3) the lipid metabolism in HCC is largely independent of lipids in blood circulation; (4) stage-specific co-expression networks for lipid metabolic genes were identified during HCC progression; and (5) the expression levels of several lipid metabolic genes that are differentially expressed or co-expressed specifically at the HCC stage have a strong correlation with cancer survival. Overall, the results provide detailed information about the reprogramed lipid metabolism in HCV-derived HCC. © Copyright © 2020 Liu, Liu, Cui and Xu.en
dc.description.sponsorshipThis work was supported by grants from the Inner Mongolia Natural Science Foundation of China (2018LH03023) and the Science Foundation for Excellent Youth Scholars of Inner Mongolia University of Science and Technology (2016YQL06).en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherFrontiers Media S.A.en
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.sourceFront. Cell Dev. Biol.2
dc.sourceFrontiers in Cell and Developmental Biologyen
dc.subjectDE NOVO SYNTHESIS OF FATTY ACIDen
dc.subjectGENE CO-EXPRESSIONen
dc.subjectGENE SET ENRICHMENTen
dc.subjectHEPATOCELLULAR CANCERen
dc.subjectLIPID METABOLISMen
dc.subjectACYL COENZYME Aen
dc.subjectAGPAT2 PROTEINen
dc.subjectAPOL2 PROTEINen
dc.subjectAPOL3 PROTEINen
dc.subjectAPOLIPOPROTEINen
dc.subjectCHOLESTEROL ESTER TRANSFER PROTEINen
dc.subjectCYTOCHROME P450 1A2en
dc.subjectCYTOCHROME P450 2A6en
dc.subjectCYTOCHROME P450 2B6en
dc.subjectCYTOCHROME P450 2C19en
dc.subjectCYTOCHROME P450 2C8en
dc.subjectFATTY ACIDen
dc.subjectFATTY ACID BINDING PROTEINen
dc.subjectGAMMA INTERFERONen
dc.subjectLIPC PROTEINen
dc.subjectLIPG PROTEINen
dc.subjectLIPIDen
dc.subjectLONG CHAIN FATTY ACIDen
dc.subjectMGLL PROTEINen
dc.subjectNICOTINAMIDE ADENINE DINUCLEOTIDEen
dc.subjectPHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASEen
dc.subjectPHOSPHOLIPID DERIVATIVEen
dc.subjectPPAP2B PROTEINen
dc.subjectPPAPDC1B PROTEINen
dc.subjectPROSTAGLANDIN Aen
dc.subjectTRIACYLGLYCEROLen
dc.subjectUNCLASSIFIED DRUGen
dc.subjectARTICLEen
dc.subjectCANCER GROWTHen
dc.subjectCANCER SURVIVALen
dc.subjectCANCER TISSUEen
dc.subjectCIRCULATIONen
dc.subjectCONTROLLED STUDYen
dc.subjectDATA ANALYSISen
dc.subjectDOWN REGULATIONen
dc.subjectFATTY ACID OXIDATIONen
dc.subjectFATTY ACID SYNTHESISen
dc.subjectGENE EXPRESSIONen
dc.subjectGENE IDENTIFICATIONen
dc.subjectHEPATITIS Cen
dc.subjectHEPATITIS C VIRUSen
dc.subjectHUMANen
dc.subjectHUMAN TISSUEen
dc.subjectLIPID METABOLISMen
dc.subjectLIPOLYSISen
dc.subjectLIVER CANCERen
dc.subjectMAJOR CLINICAL STUDYen
dc.subjectNUCLEAR REPROGRAMMINGen
dc.subjectPROTEIN EXPRESSIONen
dc.subjectTRANSCRIPTOMICSen
dc.titleTranscriptomic Data Analyses Reveal a Reprogramed Lipid Metabolism in HCV-Derived Hepatocellular Canceren
dc.typeArticleen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeinfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.3389/fcell.2020.581863-
dc.identifier.scopus85095848053-
local.contributor.employeeLiu, G., School of Life Sciences and Technology, Inner Mongolia University of Science and Technology, Baotou, China, Cancer System Biology Center, The China-Japan Union Hospital of Jilin University, Changchun, China
local.contributor.employeeLiu, G., School of Life Sciences and Technology, Inner Mongolia University of Science and Technology, Baotou, China, School of Natural Sciences and Mathematics, Ural Federal University, Yekaterinburg, Russian Federation
local.contributor.employeeCui, X., School of Life Sciences and Technology, Inner Mongolia University of Science and Technology, Baotou, China
local.contributor.employeeXu, Y., Cancer System Biology Center, The China-Japan Union Hospital of Jilin University, Changchun, China, Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, GA, United States
local.volume8-
dc.identifier.wos000587705000001-
local.contributor.departmentSchool of Life Sciences and Technology, Inner Mongolia University of Science and Technology, Baotou, China
local.contributor.departmentCancer System Biology Center, The China-Japan Union Hospital of Jilin University, Changchun, China
local.contributor.departmentSchool of Natural Sciences and Mathematics, Ural Federal University, Yekaterinburg, Russian Federation
local.contributor.departmentComputational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, GA, United States
local.identifier.pure39fb31a3-11c3-4c85-83a4-00b21dc99b71uuid
local.identifier.pure20132121-
local.description.order581863-
local.identifier.eid2-s2.0-85095848053-
local.identifier.wosWOS:000587705000001-
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