INFLUENCE EXERTED BY SOMATIC PATHOLOGY ON RISKS OF OCCUPATIONAL LUNG FIBROSIS IN WORKERS EMPLOYED AT REFRACTORY PRODUCTION

Abstract

Occupational lungs and bronchial pathology occurs not only under exposure to dusts, their aerosol structure and aggression, but also depends on individual properties of a body. The latter can determine either increased body resistance or susceptibility to occupational pathology occurrence. Our research goal was to determine influence exerted by somatic pathology on occupational lung fibrosis occurrence as well as to estimate prevalence of risk factors for cardiovascular and metabolic pathology occurrence in workers employed at refractory production. At the first stage 449 workers employed at refractory production were examined at a periodical medical examination (PME). Patients' average age was 41.59 ± 0.45 and average work experience was 14.47 ± 0.39 years. At the second stage 172 workers were examined at an occupational pathology center; 75 out of them were workers who had silicosis and were included into the test group and the remaining 97 workers didn't have any occupational pathology and were included into the reference group. Both groups were comparable as per sex (p = 0.0052) and work experience under exposure to dusts (p = 0.862). Workers examined at a PME most frequently had overweight and obesity (68 %). Arterial hypertension (AH) prevalence amounted to 19.5%; carbohydrate metabolism disorders, 19.8 %; 48.1 % workers had hypercholesterolemia. Patients with silicosis had certain disorders significantly more frequently than workers with long work experience but without any occupational pathologies; those disorders were AH, cardiac muscle hypertrophy in the left ventricle, ischemic heart disease, heart rate disorders, as well as mixed (obstructive and restrictive) breath mechanics disorders. We determined some factors that authentically produced certain effects on occupational lung fibrosis occurrence in workers employed at refractory production. Median time of silicosis occurrence was significantly shorter (by 11.5 years) among workers with severe AH, arrhythmia (by 13 years), lower hemoglobin in blood (by 11.5 years). Besides, silicosis occurred significantly earlier (by 10.8) among women than among men. © 2020 Obukhova T.Yu., Budkar' L.N., Gurvich V.B., Solodushkin S.I., Shmonina O.G., Karpova E.A.,. All Rights Reserved.