Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/102700
Title: Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D)
Authors: Xu, P.
Ianes, C.
Gärtner, F.
Liu, C.
Burster, T.
Bakulev, V.
Rachidi, N.
Knippschild, U.
Bischof, J.
Issue Date: 2019
Publisher: Elsevier B.V.
Citation: Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D) / P. Xu, C. Ianes, F. Gärtner, et al. — DOI 10.1016/j.gene.2019.144005 // Gene. — 2019. — Vol. 715. — 144005.
Abstract: Members of the highly conserved pleiotropic CK1 family of serine/threonine-specific kinases are tightly regulated in the cell and play crucial regulatory roles in multiple cellular processes from protozoa to human. Since their dysregulation as well as mutations within their coding regions contribute to the development of various different pathologies, including cancer and neurodegenerative diseases, they have become interesting new drug targets within the last decade. However, to develop optimized CK1 isoform-specific therapeutics in personalized therapy concepts, a detailed knowledge of the regulation and functions of the different CK1 isoforms, their various splice variants and orthologs is mandatory. In this review we will focus on the stress-induced CK1 isoform delta (CK1δ), thereby addressing its regulation, physiological functions, the consequences of its deregulation for the development and progression of diseases, and its potential as therapeutic drug target. © 2019 Elsevier B.V.
Keywords: CANCER
CASEIN KINASE 1
CSNK1D
HEDGEHOG PATHWAY
N
P
P53
PHOSPHORYLATION
R
S
SITE-SPECIFIC PHOSPHORYLATION
SMALL MOLECULE INHIBITOR
STRESS-INDUCED KINASE
WNT SIGNALING PATHWAY
CASEIN KINASE IDELTA
CASEIN KINASE IDELTA
ISOENZYME
TUMOR PROTEIN
AMINO ACID SEQUENCE
CARCINOGENESIS
CELL CYCLE
CELL STRESS
CELLULAR DISTRIBUTION
CIRCADIAN RHYTHM
CSNK1D GENE
CYTOSKELETON
DISEASE COURSE
DNA DAMAGE
DRUG DEPENDENCE
ENZYME REGULATION
ENZYME STRUCTURE
ENZYME SUBSTRATE
GENE SEQUENCE
GENETIC CODE
GENETIC TRANSCRIPTION
GENETIC VARIABILITY
GENETIC VARIATION
HEDGEHOG SIGNALING
HIPPO SIGNALING
HUMAN
MEIOSIS
METABOLIC DISORDER
MITOSIS
MOLECULAR RECOGNITION
NONHUMAN
PATHOPHYSIOLOGY
POLYADENYLATION
PRIORITY JOURNAL
PROTEIN INTERACTION
PROTEIN TARGETING
REVIEW
RNA FOLDING
SEQUENCE ALIGNMENT
STRESS
TUMOR GROWTH
WNT SIGNALING
ANIMAL
ANTAGONISTS AND INHIBITORS
CHEMISTRY
DRUG DELIVERY SYSTEM
ENZYMOLOGY
GENETICS
METABOLISM
NEOPLASM
PATHOLOGY
PROCEDURES
SIGNAL TRANSDUCTION
STRUCTURE ACTIVITY RELATION
ANIMALS
CASEIN KINASE IDELTA
DRUG DELIVERY SYSTEMS
HUMANS
ISOENZYMES
NEOPLASM PROTEINS
NEOPLASMS
SIGNAL TRANSDUCTION
STRUCTURE-ACTIVITY RELATIONSHIP
URI: http://hdl.handle.net/10995/102700
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85070576806
PURE ID: 10474048
d0564cb2-17b5-4755-adf3-383631e55f12
ISSN: 3781119
DOI: 10.1016/j.gene.2019.144005
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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