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dc.contributor.authorXu, P.en
dc.contributor.authorIanes, C.en
dc.contributor.authorGärtner, F.en
dc.contributor.authorLiu, C.en
dc.contributor.authorBurster, T.en
dc.contributor.authorBakulev, V.en
dc.contributor.authorRachidi, N.en
dc.contributor.authorKnippschild, U.en
dc.contributor.authorBischof, J.en
dc.date.accessioned2021-08-31T15:04:59Z-
dc.date.available2021-08-31T15:04:59Z-
dc.date.issued2019-
dc.identifier.citationStructure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D) / P. Xu, C. Ianes, F. Gärtner, et al. — DOI 10.1016/j.gene.2019.144005 // Gene. — 2019. — Vol. 715. — 144005.en
dc.identifier.issn3781119-
dc.identifier.otherFinal2
dc.identifier.otherAll Open Access, Green3
dc.identifier.otherhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85070576806&doi=10.1016%2fj.gene.2019.144005&partnerID=40&md5=ccece33b10e034be7bb5ad316b23c2f1
dc.identifier.urihttp://elar.urfu.ru/handle/10995/102700-
dc.description.abstractMembers of the highly conserved pleiotropic CK1 family of serine/threonine-specific kinases are tightly regulated in the cell and play crucial regulatory roles in multiple cellular processes from protozoa to human. Since their dysregulation as well as mutations within their coding regions contribute to the development of various different pathologies, including cancer and neurodegenerative diseases, they have become interesting new drug targets within the last decade. However, to develop optimized CK1 isoform-specific therapeutics in personalized therapy concepts, a detailed knowledge of the regulation and functions of the different CK1 isoforms, their various splice variants and orthologs is mandatory. In this review we will focus on the stress-induced CK1 isoform delta (CK1δ), thereby addressing its regulation, physiological functions, the consequences of its deregulation for the development and progression of diseases, and its potential as therapeutic drug target. © 2019 Elsevier B.V.en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.sourceGene2
dc.sourceGeneen
dc.subjectCANCERen
dc.subjectCASEIN KINASE 1en
dc.subjectCSNK1Den
dc.subjectHEDGEHOG PATHWAYen
dc.subjectNen
dc.subjectPen
dc.subjectP53en
dc.subjectPHOSPHORYLATIONen
dc.subjectRen
dc.subjectSen
dc.subjectSITE-SPECIFIC PHOSPHORYLATIONen
dc.subjectSMALL MOLECULE INHIBITORen
dc.subjectSTRESS-INDUCED KINASEen
dc.subjectWNT SIGNALING PATHWAYen
dc.subjectCASEIN KINASE IDELTAen
dc.subjectCASEIN KINASE IDELTAen
dc.subjectISOENZYMEen
dc.subjectTUMOR PROTEINen
dc.subjectAMINO ACID SEQUENCEen
dc.subjectCARCINOGENESISen
dc.subjectCELL CYCLEen
dc.subjectCELL STRESSen
dc.subjectCELLULAR DISTRIBUTIONen
dc.subjectCIRCADIAN RHYTHMen
dc.subjectCSNK1D GENEen
dc.subjectCYTOSKELETONen
dc.subjectDISEASE COURSEen
dc.subjectDNA DAMAGEen
dc.subjectDRUG DEPENDENCEen
dc.subjectENZYME REGULATIONen
dc.subjectENZYME STRUCTUREen
dc.subjectENZYME SUBSTRATEen
dc.subjectGENE SEQUENCEen
dc.subjectGENETIC CODEen
dc.subjectGENETIC TRANSCRIPTIONen
dc.subjectGENETIC VARIABILITYen
dc.subjectGENETIC VARIATIONen
dc.subjectHEDGEHOG SIGNALINGen
dc.subjectHIPPO SIGNALINGen
dc.subjectHUMANen
dc.subjectMEIOSISen
dc.subjectMETABOLIC DISORDERen
dc.subjectMITOSISen
dc.subjectMOLECULAR RECOGNITIONen
dc.subjectNONHUMANen
dc.subjectPATHOPHYSIOLOGYen
dc.subjectPOLYADENYLATIONen
dc.subjectPRIORITY JOURNALen
dc.subjectPROTEIN INTERACTIONen
dc.subjectPROTEIN TARGETINGen
dc.subjectREVIEWen
dc.subjectRNA FOLDINGen
dc.subjectSEQUENCE ALIGNMENTen
dc.subjectSTRESSen
dc.subjectTUMOR GROWTHen
dc.subjectWNT SIGNALINGen
dc.subjectANIMALen
dc.subjectANTAGONISTS AND INHIBITORSen
dc.subjectCHEMISTRYen
dc.subjectDRUG DELIVERY SYSTEMen
dc.subjectENZYMOLOGYen
dc.subjectGENETICSen
dc.subjectMETABOLISMen
dc.subjectNEOPLASMen
dc.subjectPATHOLOGYen
dc.subjectPROCEDURESen
dc.subjectSIGNAL TRANSDUCTIONen
dc.subjectSTRUCTURE ACTIVITY RELATIONen
dc.subjectANIMALSen
dc.subjectCASEIN KINASE IDELTAen
dc.subjectDRUG DELIVERY SYSTEMSen
dc.subjectHUMANSen
dc.subjectISOENZYMESen
dc.subjectNEOPLASM PROTEINSen
dc.subjectNEOPLASMSen
dc.subjectSIGNAL TRANSDUCTIONen
dc.subjectSTRUCTURE-ACTIVITY RELATIONSHIPen
dc.titleStructure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D)en
dc.typeReviewen
dc.typeinfo:eu-repo/semantics/reviewen
dc.typeinfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.1016/j.gene.2019.144005-
dc.identifier.scopus85070576806-
local.contributor.employeeXu, P., Department of General and Visceral Surgery, Surgery Center, Ulm University Hospital, Albert-Einstein-Allee 23, Ulm, 89081, Germany
local.contributor.employeeIanes, C., Department of General and Visceral Surgery, Surgery Center, Ulm University Hospital, Albert-Einstein-Allee 23, Ulm, 89081, Germany
local.contributor.employeeGärtner, F., Department of General and Visceral Surgery, Surgery Center, Ulm University Hospital, Albert-Einstein-Allee 23, Ulm, 89081, Germany
local.contributor.employeeLiu, C., Department of General and Visceral Surgery, Surgery Center, Ulm University Hospital, Albert-Einstein-Allee 23, Ulm, 89081, Germany
local.contributor.employeeBurster, T., Department of Biology, School of Science and Technology, Nazarbayev University, 53 Kabanbay Batyr Ave, Nur-Sultan, 020000, Kazakhstan
local.contributor.employeeBakulev, V., Ural Federal University named after the first President of Russia B. N. Eltsin, Technology for Organic Synthesis Laboratory, 19 Mirastr., Ekaterinburg, 620002, Russian Federation
local.contributor.employeeRachidi, N., Unité de Parasitologie Moléculaire et Signalisation, Department of Parasites and Insect Vectors, Institut Pasteur and INSERM U1201, 25-28 Rue du Dr Roux, Paris, 75015, France
local.contributor.employeeKnippschild, U., Department of General and Visceral Surgery, Surgery Center, Ulm University Hospital, Albert-Einstein-Allee 23, Ulm, 89081, Germany
local.contributor.employeeBischof, J., Department of General and Visceral Surgery, Surgery Center, Ulm University Hospital, Albert-Einstein-Allee 23, Ulm, 89081, Germany
local.volume715-
local.contributor.departmentDepartment of General and Visceral Surgery, Surgery Center, Ulm University Hospital, Albert-Einstein-Allee 23, Ulm, 89081, Germany
local.contributor.departmentDepartment of Biology, School of Science and Technology, Nazarbayev University, 53 Kabanbay Batyr Ave, Nur-Sultan, 020000, Kazakhstan
local.contributor.departmentUral Federal University named after the first President of Russia B. N. Eltsin, Technology for Organic Synthesis Laboratory, 19 Mirastr., Ekaterinburg, 620002, Russian Federation
local.contributor.departmentUnité de Parasitologie Moléculaire et Signalisation, Department of Parasites and Insect Vectors, Institut Pasteur and INSERM U1201, 25-28 Rue du Dr Roux, Paris, 75015, France
local.identifier.pure10474048-
local.identifier.pured0564cb2-17b5-4755-adf3-383631e55f12uuid
local.description.order144005-
local.identifier.eid2-s2.0-85070576806-
local.identifier.pmid31376410-
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