Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/102140
Title: Synthesis, characterization and in vivo evaluation of biocompatible ferrogels
Authors: Lopez-Lopez, M. T.
Rodriguez, I. A.
Rodriguez-Arco, L.
Carriel, V.
Bonhome-Espinosa, A. B.
Campos, F.
Zubarev, A.
Duran, J. D. G.
Issue Date: 2017
Publisher: Elsevier B.V.
Citation: Synthesis, characterization and in vivo evaluation of biocompatible ferrogels / M. T. Lopez-Lopez, I. A. Rodriguez, L. Rodriguez-Arco, et al. — DOI 10.1016/j.jmmm.2016.08.053 // Journal of Magnetism and Magnetic Materials. — 2017. — Vol. 431. — P. 110-114.
Abstract: A hydrogel is a 3-D network of polymer chains in which water is the dispersion medium. Hydrogels have found extensive applications in the biomedical field due to their resemblance to living tissues. Furthermore, hydrogels can be endowed with exceptional properties by addition of synthetic materials. For example, magnetic field-sensitive gels, called ferrogels, are obtained by embedding magnetic particles in the polymer network. Novel living tissues with unique magnetic field-sensitive properties were recently prepared by 3-D cell culture in biocompatible ferrogels. This paper critically reviews the most recent progress and perspectives in their synthesis, characterization and biocompatibility evaluation. Optimization of ferrogels for this novel application requires low-density, strongly magnetic, multi-domain particles. Interestingly, the rheological properties of the resulting ferrogels in the absence of field were largely enhanced with respect to nonmagnetic hydrogels, which can only be explained by the additional cross-linking imparted by the embedded magnetic particles. Remarkably, rheological measurements under an applied magnetic field demonstrated that ferrogels presented reversibly tunable mechanical properties, which constitutes a unique advantage with respect to nonmagnetic hydrogels. In vivo evaluation of ferrogels showed good biocompatibility, with only some local inflammatory response, and no particle migration or damage to distant organs. © 2016 Elsevier B.V.
Keywords: FERROGEL
IN VIVO
MAGNETIC PARTICLE
MAGNETORHEOLOGY
POLYMER
RHEOLOGY
BIOCOMPATIBILITY
BIOMECHANICS
CELL CULTURE
HISTOLOGY
HYDROGELS
MAGNETIC FIELDS
MAGNETISM
POLYMERS
RHEOLOGY
TISSUE
APPLIED MAGNETIC FIELDS
FERROGEL
IN-VIVO
INFLAMMATORY RESPONSE
MAGNETIC PARTICLE
MAGNETO-RHEOLOGY
RHEOLOGICAL MEASUREMENTS
RHEOLOGICAL PROPERTY
MAGNETIC BUBBLES
URI: http://hdl.handle.net/10995/102140
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85015737352
PURE ID: 1691284
facf6479-07df-478f-8cfe-cd802789ecd1
ISSN: 3048853
DOI: 10.1016/j.jmmm.2016.08.053
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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