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http://elar.urfu.ru/handle/10995/101445
Название: | Rapid prototyping of soft bioelectronic implants for use as neuromuscular interfaces |
Авторы: | Afanasenkau, D. Kalinina, D. Lyakhovetskii, V. Tondera, C. Gorsky, O. Moosavi, S. Pavlova, N. Merkulyeva, N. Kalueff, A. V. Minev, I. R. Musienko, P. |
Дата публикации: | 2020 |
Издатель: | Nature Research |
Библиографическое описание: | Rapid prototyping of soft bioelectronic implants for use as neuromuscular interfaces / D. Afanasenkau, D. Kalinina, V. Lyakhovetskii, et al. — DOI 10.1038/s41551-020-00615-7 // Nature Biomedical Engineering. — 2020. — Vol. 4. — Iss. 10. — P. 1010-1022. |
Аннотация: | Neuromuscular interfaces are required to translate bioelectronic technologies for application in clinical medicine. Here, by leveraging the robotically controlled ink-jet deposition of low-viscosity conductive inks, extrusion of insulating silicone pastes and in situ activation of electrode surfaces via cold-air plasma, we show that soft biocompatible materials can be rapidly printed for the on-demand prototyping of customized electrode arrays well adjusted to specific anatomical environments, functions and experimental models. We also show, with the monitoring and activation of neuronal pathways in the brain, spinal cord and neuromuscular system of cats, rats and zebrafish, that the printed bioelectronic interfaces allow for long-term integration and functional stability. This technology might enable personalized bioelectronics for neuroprosthetic applications. © 2020, The Author(s), under exclusive licence to Springer Nature Limited. |
Ключевые слова: | BIOCOMPATIBILITY CHEMICAL ACTIVATION ELECTRODES INK JET PRINTERS MEDICINE SILICONES BIO-ELECTRONIC INTERFACE CLINICAL MEDICINE ELECTRODE ARRAYS ELECTRODE SURFACES EXPERIMENTAL MODELS INK-JET DEPOSITION LONG-TERM INTEGRATION NEUROMUSCULAR SYSTEMS INK BIOMATERIAL INK NANOWIRE SILASTIC SILICONE TOOTH CEMENT BIOMATERIAL ANIMAL EXPERIMENT ANIMAL TISSUE ARTICLE BIOCOMPATIBILITY BIOPRINTING CAT CYCLIC VOLTAMMETRY DURA MATER ELECTRIC POTENTIAL ELECTROCORTICOGRAPHY ELECTROMYOGRAM FIELD EMISSION SCANNING ELECTRON MICROSCOPY IMAGE ANALYSIS IMMUNOHISTOCHEMISTRY IMPEDANCE SPECTROSCOPY LOCOMOTION MALE MUSCLE CONTRACTION NERVE CELL NETWORK NERVOUS SYSTEM INFLAMMATION NEUROANATOMY NEUROMODULATION NEUROMUSCULAR SYSTEM NEUROPHYSIOLOGY NONHUMAN PLASMA GAS RAPID PROTOTYPING RAT SOFTWARE SPINAL CORD STIMULATION VISCOSITY ZEBRA FISH ANIMAL BLADDER DEVICES ELECTROSTIMULATION EQUIPMENT DESIGN FEMALE NEUROMUSCULAR MONITORING PHYSIOLOGY PROCEDURES PROSTHESES AND ORTHOSES SCIATIC NERVE SPINAL CORD THREE DIMENSIONAL PRINTING WISTAR RAT ANIMALS BIOCOMPATIBLE MATERIALS CATS DIELECTRIC SPECTROSCOPY ELECTRIC STIMULATION EQUIPMENT DESIGN FEMALE INK MALE NEUROMUSCULAR MONITORING PRINTING, THREE-DIMENSIONAL PROSTHESES AND IMPLANTS RATS, WISTAR SCIATIC NERVE SPINAL CORD URINARY BLADDER ZEBRAFISH |
URI: | http://elar.urfu.ru/handle/10995/101445 |
Условия доступа: | info:eu-repo/semantics/openAccess |
Идентификатор SCOPUS: | 85091197760 |
Идентификатор WOS: | 000571688300001 |
Идентификатор PURE: | 5ce8e2ea-b42f-4b8f-a0dd-51f0c01cbd34 20126590 |
ISSN: | 2157846X |
DOI: | 10.1038/s41551-020-00615-7 |
Сведения о поддержке: | We acknowledge funding from the following sources: the European Research Council (804005; IntegraBrain), Saint-Petersburg State University (project 51134206; funding to O.G. and N.M. for animal facility and biocompatibility studies, and validation of the implants on in vivo models), Technische Universität Dresden, the Russian Foundation for Basic Research (grants 20-015-00568-a (for the urodynamic study) and 18-33-20062-mol_a_ved (for developing the optimal electrode array configuration)), Deutsche Forschungsgemeinschaft (MI 2117/1-1) and the Volkswagen Foundation (Freigeist 91 690). We thank D. E. Korzhevskiy (immunohistochemistry), Y. I. Sysoev (zebrafish model), A. V. Goriainova (functional tests) and T. Kurth (electron microscopy) for help and expertise. |
Располагается в коллекциях: | Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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2-s2.0-85091197760.pdf | 3,49 MB | Adobe PDF | Просмотреть/Открыть |
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