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Название: Rapid prototyping of soft bioelectronic implants for use as neuromuscular interfaces
Авторы: Afanasenkau, D.
Kalinina, D.
Lyakhovetskii, V.
Tondera, C.
Gorsky, O.
Moosavi, S.
Pavlova, N.
Merkulyeva, N.
Kalueff, A. V.
Minev, I. R.
Musienko, P.
Дата публикации: 2020
Издатель: Nature Research
Библиографическое описание: Rapid prototyping of soft bioelectronic implants for use as neuromuscular interfaces / D. Afanasenkau, D. Kalinina, V. Lyakhovetskii, et al. — DOI 10.1038/s41551-020-00615-7 // Nature Biomedical Engineering. — 2020. — Vol. 4. — Iss. 10. — P. 1010-1022.
Аннотация: Neuromuscular interfaces are required to translate bioelectronic technologies for application in clinical medicine. Here, by leveraging the robotically controlled ink-jet deposition of low-viscosity conductive inks, extrusion of insulating silicone pastes and in situ activation of electrode surfaces via cold-air plasma, we show that soft biocompatible materials can be rapidly printed for the on-demand prototyping of customized electrode arrays well adjusted to specific anatomical environments, functions and experimental models. We also show, with the monitoring and activation of neuronal pathways in the brain, spinal cord and neuromuscular system of cats, rats and zebrafish, that the printed bioelectronic interfaces allow for long-term integration and functional stability. This technology might enable personalized bioelectronics for neuroprosthetic applications. © 2020, The Author(s), under exclusive licence to Springer Nature Limited.
Ключевые слова: BIOCOMPATIBILITY
CHEMICAL ACTIVATION
ELECTRODES
INK JET PRINTERS
MEDICINE
SILICONES
BIO-ELECTRONIC INTERFACE
CLINICAL MEDICINE
ELECTRODE ARRAYS
ELECTRODE SURFACES
EXPERIMENTAL MODELS
INK-JET DEPOSITION
LONG-TERM INTEGRATION
NEUROMUSCULAR SYSTEMS
INK
BIOMATERIAL
INK
NANOWIRE
SILASTIC
SILICONE
TOOTH CEMENT
BIOMATERIAL
ANIMAL EXPERIMENT
ANIMAL TISSUE
ARTICLE
BIOCOMPATIBILITY
BIOPRINTING
CAT
CYCLIC VOLTAMMETRY
DURA MATER
ELECTRIC POTENTIAL
ELECTROCORTICOGRAPHY
ELECTROMYOGRAM
FIELD EMISSION SCANNING ELECTRON MICROSCOPY
IMAGE ANALYSIS
IMMUNOHISTOCHEMISTRY
IMPEDANCE SPECTROSCOPY
LOCOMOTION
MALE
MUSCLE CONTRACTION
NERVE CELL NETWORK
NERVOUS SYSTEM INFLAMMATION
NEUROANATOMY
NEUROMODULATION
NEUROMUSCULAR SYSTEM
NEUROPHYSIOLOGY
NONHUMAN
PLASMA GAS
RAPID PROTOTYPING
RAT
SOFTWARE
SPINAL CORD STIMULATION
VISCOSITY
ZEBRA FISH
ANIMAL
BLADDER
DEVICES
ELECTROSTIMULATION
EQUIPMENT DESIGN
FEMALE
NEUROMUSCULAR MONITORING
PHYSIOLOGY
PROCEDURES
PROSTHESES AND ORTHOSES
SCIATIC NERVE
SPINAL CORD
THREE DIMENSIONAL PRINTING
WISTAR RAT
ANIMALS
BIOCOMPATIBLE MATERIALS
CATS
DIELECTRIC SPECTROSCOPY
ELECTRIC STIMULATION
EQUIPMENT DESIGN
FEMALE
INK
MALE
NEUROMUSCULAR MONITORING
PRINTING, THREE-DIMENSIONAL
PROSTHESES AND IMPLANTS
RATS, WISTAR
SCIATIC NERVE
SPINAL CORD
URINARY BLADDER
ZEBRAFISH
URI: http://elar.urfu.ru/handle/10995/101445
Условия доступа: info:eu-repo/semantics/openAccess
Идентификатор SCOPUS: 85091197760
Идентификатор WOS: 000571688300001
Идентификатор PURE: 5ce8e2ea-b42f-4b8f-a0dd-51f0c01cbd34
20126590
ISSN: 2157846X
DOI: 10.1038/s41551-020-00615-7
Сведения о поддержке: We acknowledge funding from the following sources: the European Research Council (804005; IntegraBrain), Saint-Petersburg State University (project 51134206; funding to O.G. and N.M. for animal facility and biocompatibility studies, and validation of the implants on in vivo models), Technische Universität Dresden, the Russian Foundation for Basic Research (grants 20-015-00568-a (for the urodynamic study) and 18-33-20062-mol_a_ved (for developing the optimal electrode array configuration)), Deutsche Forschungsgemeinschaft (MI 2117/1-1) and the Volkswagen Foundation (Freigeist 91 690). We thank D. E. Korzhevskiy (immunohistochemistry), Y. I. Sysoev (zebrafish model), A. V. Goriainova (functional tests) and T. Kurth (electron microscopy) for help and expertise.
Располагается в коллекциях:Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

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