Electromechanical coupling in cardiomyocytes depends on its electrotonic interaction with fibroblasts

Abstract

Cardiac fibroblasts can influence cardiomyocyte electrical activity. Existing mathemati-cal models of fibroblast-cardiomyocyte interaction allow analyzing only electrical responses of effect cardiomyocytes and fibroblasts to their electrical interaction. In our work, we exam-ined fibroblast on the cardiomyocyte mechanics by modelling. We got significant changes in both action potential duration and force generation in the cardiomyocyte depending on the number of fibroblasts connected with it.