Synthesis, aggregation and chymotrypsin inhibition by tryptophan derivatives of thiacalix[4]arene

Abstract

Modulation of the catalytic activity of enzymes is widely used in various fields of human activity, such as medical applications, in agriculture and food industry. Currently, the attention of researchers has shifted to the search for modulators of enzyme activity based on polyfunctional building blocks, such as fullerenes, nanotubes, macrocyclic compounds. The attractiveness of macrocycles is due to their structural features, which make it easy to fix the spatial arrangement of large number of binding groups, capable of providing non-covalent interactions with guest molecules, which makes it possible to create ligands based on them for various kinds of biomolecules, including enzymes.