Lithium 3-polyfluoroalkyl-1,3-diketonates as a valuable building blocks

Abstract

Previously, we have introduced lithium 3-polyfluoroalkyl-1,3-diketonates (LDKs) in organic synthesis as building blocks and demonstrated benefits of their use compared to appropriate 1,3-diketones. They are readily accessible, stable on storage, and highly reactive. On the bases on LDKs, we have developed facile syntheses methods of fluoroalkyl-containing polyfunctional compounds [1–8], various linear and annulated heterocycles [1, 9–14]. We have significantly expanded the synthetic capabilities of LDKs 1 through nitrosation reactions and developed effective methods for the synthesis of 5-hydroxy-5-(polyfluoroalkyl)isoxazol-4(5H)-one oximes 3 [14], 4-amino-pyrazoles 4, quinoxaline derivatives 5 and 6 [14] and new heterocyclic systems 7 and 8.