APPLICATION OF GALVANOSTATIC COULOMETRY FOR DETERMINATION OF PHENOLIC COMPOUNDS IN MEDICINAL PREPARATIONS

Abstract

The objects of the study were: rutin - as a representative of the class of flavonoids and polyphenols; salicylic acid as a representative of phenolic acids and drugs containing phenolic compounds such as “Ascorutin”, “Salicylic Paste” and “Salicylic Ointment”. The titrants used were electrogenated halogens (Cl2, Br2 and I2) and hexacyanoferrate (III) ions. Generation was carried out at a constant current strength of I = 10 mA, and the equivalence point was fixed biamperometrically with two polarized electrodes on the coulometric analyzer “Expert-006”. The selected halogens are not only capable of oxidizing phenolic compounds, but also enter into electrophilic substitution reactions of the benzene ring, while the hexacyanoferrate(III)-ions [Fe (CN)6]3- are mild oxidizing agents.