NOVEL 8-NITROSUBSTITUTED 1, 3-BENZOTHIAZIN-4-ONES

Abstract

Many synthetic benzothiazines play an important role in the treatment of various diseases. Some 2-amino substituted 1, 3-benzothiazin-4-ones (2-amino-1, 3-benzothiazinones) represent a promising new class of antitubercular agents. Recently we have reported the synthesis of novel fluorinated 2-cycloalkylaminosubstituted 1, 3-benzothiazin-4-ones through the addition of N-nucleophiles to ortho-fluorobenzoylisothiocyanates and subsequent cyclization of fluorobenzoyl-thioureas, and 5-fluoro-2-(4-ethoxycarbonylpiperazin-1-yl)-1, 3-benzothiazin-4-one was chosen as leading compound.