NEW AXIALLY CHIRAL BIPYRIDINES AND THEIR APPLICATION IN ASYMMETRIC CATALYSIS

Abstract

Complexes of chiral bipyridines with transition metals have a very rich chemistry including catalytic asymmetric transformations[1]. Additionally, related bypiridine N-oxides have made a considerable impact in enantioselective nucleophilic catalysis[2]. Despite these successes, synthesis and application of axially chiral bipyridine derivatives has not reached the level of maturity, which in part is due to the lack of good coupling methods for joining the pyridine units together in a stereoselective fashion.