Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на этот ресурс: http://elar.urfu.ru/handle/10995/92592
Полная запись метаданных
Поле DCЗначениеЯзык
dc.contributor.authorZakaly, H. M. H.en
dc.contributor.authorMostafa, M. Y. A.en
dc.contributor.authorZhukovsky, M.en
dc.date.accessioned2020-10-20T16:36:25Z-
dc.date.available2020-10-20T16:36:25Z-
dc.date.issued2019-
dc.identifier.citationZakaly H. M. H. Internal Dosimetry assessment for monoclonal antibodies and antibody fragments labeled by Lutetium-177 / H. M. H. Zakaly, M. Y. A. Mostafa, M. Zhukovsky. — DOI 10.1088/1742-6596/1353/1/012078 // Journal of Physics: Conference Series. — 2019. — Vol. 1. — Iss. 1353. — 12078.en
dc.identifier.issn1742-6588-
dc.identifier.otherhttps://doi.org/10.1088/1742-6596/1353/1/012078pdf
dc.identifier.other1good_DOI
dc.identifier.otherf7455d23-ae82-4794-be90-01c95e1aa28bpure_uuid
dc.identifier.otherhttp://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85075531401m
dc.identifier.urihttp://elar.urfu.ru/handle/10995/92592-
dc.description.abstractIn this research, the behaviour of monoclonal antibodies (MAbs) and their fragments labeled by 177Lu after injecting into the body is simulated for diagnostic and therapy. The absorbed doses in organs and tissues with maximum radiation exposure are presented. On the base of reference data in the literature, a biokinetic model is built-in for MAb and their fragments. The cumulative activity of 177Lu in organs and tissues per Bq of administered activity is calculated. Spleen, liver, and red bone marrow have the highest doses when 177Lu associated with intact monoclonal antibodies is injected into human body. The estimated doses on these organs are 1.95, 1.17 and 0.54 mGy/MBq, respectively. For the fragments of monoclonal antibodies is considered with 177Lu, the most exposed organs are the kidneys with the doses of 0.78 mGy/MBq for F(ab')) and 1.27 mGy/MBq for F(ab′)2. © 2019 Published under licence by IOP Publishing Ltd.en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherInstitute of Physics Publishingen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.sourceJournal of Physics: Conference Seriesen
dc.subjectHISTOLOGYen
dc.subjectINDUSTRIAL RESEARCHen
dc.subjectLUTETIUMen
dc.subjectMANUFACTUREen
dc.subjectMONOCLONAL ANTIBODIESen
dc.subjectSURFACE PLASMON RESONANCEen
dc.subjectTISSUEen
dc.subjectABSORBED DOSEen
dc.subjectANTIBODY FRAGMENTen
dc.subjectBIOKINETIC MODELSen
dc.subjectBONE MARROWen
dc.subjectHUMAN BODIESen
dc.subjectMONOCLONAL ANTIBODIES (MABS)en
dc.subjectRADIATION EXPOSUREen
dc.subjectREFERENCE DATAen
dc.subjectBEHAVIORAL RESEARCHen
dc.titleInternal Dosimetry assessment for monoclonal antibodies and antibody fragments labeled by Lutetium-177en
dc.typeConference Paperen
dc.typeinfo:eu-repo/semantics/conferenceObjecten
dc.typeinfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.1088/1742-6596/1353/1/012078-
dc.identifier.scopus85075531401-
local.affiliationInstitute of Physics and Technology, Ural Federal University, 19 Mira str., Yekaterinburg, 620002, Russian Federation
local.affiliationPhysics Department, Faculty of Science, Al-Azhar University, Assuit Branch, Assuit, 71524, Egypt
local.affiliationInstitute of Industrial Ecology UB RAS, 20 Sophy Kovalevskoy str., Ekaterinburg, 620990, Russian Federation
local.affiliationMinia University, Faculty of Science, Department of Physics, El-Minia, Egypt
local.contributor.employeeZakaly, H.M.H., Institute of Physics and Technology, Ural Federal University, 19 Mira str., Yekaterinburg, 620002, Russian Federation, Physics Department, Faculty of Science, Al-Azhar University, Assuit Branch, Assuit, 71524, Egypt
local.contributor.employeeMostafa, M.Y.A., Institute of Physics and Technology, Ural Federal University, 19 Mira str., Yekaterinburg, 620002, Russian Federation, Minia University, Faculty of Science, Department of Physics, El-Minia, Egypt
local.contributor.employeeZhukovsky, M., Institute of Physics and Technology, Ural Federal University, 19 Mira str., Yekaterinburg, 620002, Russian Federation, Institute of Industrial Ecology UB RAS, 20 Sophy Kovalevskoy str., Ekaterinburg, 620990, Russian Federation
local.issue1353-
local.volume1-
local.identifier.pure11331077-
local.description.order12078-
local.identifier.eid2-s2.0-85075531401-
Располагается в коллекциях:Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

Файлы этого ресурса:
Файл Описание РазмерФормат 
10.1088-1742-6596-1353-1-012078.pdf569,77 kBAdobe PDFПросмотреть/Открыть


Все ресурсы в архиве электронных ресурсов защищены авторским правом, все права сохранены.