Please use this identifier to cite or link to this item:
|Title:||Organism's responses to a long-term inhalation of silica-containing submicron particles of an industrial aerosol|
|Authors:||Solovyeva, S. N.|
Katsnelson, B. A.
Sutunkova, M. P.
Privalova, L. I.
Gurvich, V. B.
Minigalieva, I. A.
Slyshkina, T. V.
Valamina, I. E.
Shur, V. Y.
Zubarev, I. V.
Kuznetsov, D. K.
|Publisher:||Institute of Physics Publishing|
|Citation:||Organism's responses to a long-term inhalation of silica-containing submicron particles of an industrial aerosol / S. N. Solovyeva, B. A. Katsnelson, M. P. Sutunkova, L. I. Privalova, et al.. — DOI 10.1088/1757-899X/699/1/012054 // IOP Conference Series: Materials Science and Engineering. — 2019. — Vol. 1. — Iss. 699. — 12054.|
|Abstract:||Female white rats were exposed during up to 6 months 5 times a week, 4 hr per day in a "nose only" inhalation device to an aerosol containing predominantly submicron (nanoscale included) particles of amorphous silica in the concentration 2.6±0.6 or 10.6±2.1 mg/m3. In an auxiliary experiment with a single-shot intratracheal instillation of these particles, it was shown that they induced a pulmonary cell response comparable with that to highly cytotoxic and fibrogenic standard quartz powder DQ12. However, in the long-term inhalation test, the studied aerosol proved to be of very low systemic toxicity and fibrogenicity. This paradox may be explained by low SiO2 retention in lungs and other organs due to a relatively high in vivo solubility of these nanoparticles. Nevertheless, their genotoxic action and transnasal penetration into the brain should make one give a cautious overall assessment of this aerosol as an occupational or environmental hazard. © Published under licence by IOP Publishing Ltd.|
|metadata.dc.description.sponsorship:||Government Council on Grants, Russian Federation|
Ministry of Science and Higher Education of the Russian Federation: 3.9534.2017/8.9
The research was partially supported by the Ministry of Science and Higher Education of the Russian Federation (project 3.9534.2017/8.9) and by Government of the Russian Federation (Act 211, Agreement 02.A03.21.0006). The equipment of the Ural Centre for Shared Use “Modern Nanotechnology” UrFU was used.
|Appears in Collections:||Научные публикации, проиндексированные в SCOPUS и WoS CC|
Files in This Item:
|10.1088-1757-899X-699-1-012054.pdf||1,35 MB||Adobe PDF||View/Open|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.