Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/92315
Title: Organism's responses to a long-term inhalation of silica-containing submicron particles of an industrial aerosol
Authors: Solovyeva, S. N.
Katsnelson, B. A.
Sutunkova, M. P.
Privalova, L. I.
Gurvich, V. B.
Minigalieva, I. A.
Slyshkina, T. V.
Valamina, I. E.
Shur, V. Y.
Zubarev, I. V.
Kuznetsov, D. K.
Issue Date: 2019
Publisher: Institute of Physics Publishing
Citation: Organism's responses to a long-term inhalation of silica-containing submicron particles of an industrial aerosol / S. N. Solovyeva, B. A. Katsnelson, M. P. Sutunkova, L. I. Privalova, et al.. — DOI 10.1088/1757-899X/699/1/012054 // IOP Conference Series: Materials Science and Engineering. — 2019. — Vol. 1. — Iss. 699. — 12054.
Abstract: Female white rats were exposed during up to 6 months 5 times a week, 4 hr per day in a "nose only" inhalation device to an aerosol containing predominantly submicron (nanoscale included) particles of amorphous silica in the concentration 2.6±0.6 or 10.6±2.1 mg/m3. In an auxiliary experiment with a single-shot intratracheal instillation of these particles, it was shown that they induced a pulmonary cell response comparable with that to highly cytotoxic and fibrogenic standard quartz powder DQ12. However, in the long-term inhalation test, the studied aerosol proved to be of very low systemic toxicity and fibrogenicity. This paradox may be explained by low SiO2 retention in lungs and other organs due to a relatively high in vivo solubility of these nanoparticles. Nevertheless, their genotoxic action and transnasal penetration into the brain should make one give a cautious overall assessment of this aerosol as an occupational or environmental hazard. © Published under licence by IOP Publishing Ltd.
URI: http://hdl.handle.net/10995/92315
metadata.dc.rights: info:eu-repo/semantics/openAccess
SCOPUS ID: 85078222001
PURE ID: 12010505
ISSN: 1757-8981
DOI: 10.1088/1757-899X/699/1/012054
metadata.dc.description.sponsorship: Government Council on Grants, Russian Federation
Ministry of Science and Higher Education of the Russian Federation: 3.9534.2017/8.9
The research was partially supported by the Ministry of Science and Higher Education of the Russian Federation (project 3.9534.2017/8.9) and by Government of the Russian Federation (Act 211, Agreement 02.A03.21.0006). The equipment of the Ural Centre for Shared Use “Modern Nanotechnology” UrFU was used.
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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