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|Title:||Ferrogels ultrasonography for biomedical applications|
|Authors:||Blyakhman, F. A.|
Sokolov, S. Y.
Safronov, A. P.
Dinislamova, O. A.
Shklyar, T. F.
Zubarev, A. Y.
Kurlyandskaya, G. V.
Сафронов, А. П.
|Citation:||Ferrogels ultrasonography for biomedical applications / F. A. Blyakhman, S. Y. Sokolov, A. P. Safronov, O. A. Dinislamova, et al. . — DOI 10.3390/s19183959 // Sensors (Switzerland). — 2019. — Vol. 18. — Iss. 19. — 3959.|
|Abstract:||Ferrogels (FG) are magnetic composites that are widely used in the area of biomedical engineering and biosensing. In this work, ferrogels with different concentrations of magnetic nanoparticles (MNPs) were synthesized by the radical polymerization of acrylamide in stabilized aqueous ferrofluid. FG samples were prepared in various shapes that are suitable for different characterization techniques. Thin cylindrical samples were used to simulate the case of targeted drug delivery test through blood vessels. Samples of larger size that were in the shape of cylindrical plates were used for the evaluation of the FG applicability as substitutes for damaged structures, such as bone or cartilage tissues. Regardless of the shape of the samples and the conditions of their location, the boundaries of FG were confidently visualized over the entire range of concentrations of MNPs while using medical ultrasound. The amplitude of the reflected echo signal was higher for the higher concentration of MNPs in the gel. This result was not related to the influence of the MNPs on the intensity of the reflected echo signal directly, since the wavelength of the ultrasonic effect used is much larger than the particle size. Qualitative theoretical model for the understanding of the experimental results was proposed while taking into account the concept that at the acoustic oscillations of the hydrogel, the macromolecular net, and water in the gel porous structure experience the viscous Stocks-like interaction. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.|
TARGETED DRUG DELIVERY
MAGNETIC NANOPARTI CLES (MNPS)
Ministry of Education and Science of the Russian Federation, Minobrnauka: 3.1438.2017/46
Funding: The Russian Scientific Foundation (grant 18-19-00090) supported the experimental parts of this study, including the design, performance and analysis of experiments.
Acknowledgments: A.Yu. Zubarev thanks the program of the Ministry of Education and Science of the Russian Federation (project 3.1438.2017/46) for the support of his mathematical studies. We thank K.R. Mekhdieva, P.A. Shabadrov, V.Ya. Krokhalev, I.V. Beketov and A.M. Murzakaev for special support.
|RSCF project card:||18-19-00090|
|Appears in Collections:||Научные публикации, проиндексированные в SCOPUS и WoS CC|
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