Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/90670
Title: Ferrogels ultrasonography for biomedical applications
Authors: Blyakhman, F. A.
Sokolov, S. Y.
Safronov, A. P.
Dinislamova, O. A.
Shklyar, T. F.
Zubarev, A. Y.
Kurlyandskaya, G. V.
Сафронов, А. П.
Issue Date: 2019
Publisher: MDPI AG
Citation: Ferrogels ultrasonography for biomedical applications / F. A. Blyakhman, S. Y. Sokolov, A. P. Safronov, O. A. Dinislamova, et al. . — DOI 10.3390/s19183959 // Sensors (Switzerland). — 2019. — Vol. 18. — Iss. 19. — 3959.
Abstract: Ferrogels (FG) are magnetic composites that are widely used in the area of biomedical engineering and biosensing. In this work, ferrogels with different concentrations of magnetic nanoparticles (MNPs) were synthesized by the radical polymerization of acrylamide in stabilized aqueous ferrofluid. FG samples were prepared in various shapes that are suitable for different characterization techniques. Thin cylindrical samples were used to simulate the case of targeted drug delivery test through blood vessels. Samples of larger size that were in the shape of cylindrical plates were used for the evaluation of the FG applicability as substitutes for damaged structures, such as bone or cartilage tissues. Regardless of the shape of the samples and the conditions of their location, the boundaries of FG were confidently visualized over the entire range of concentrations of MNPs while using medical ultrasound. The amplitude of the reflected echo signal was higher for the higher concentration of MNPs in the gel. This result was not related to the influence of the MNPs on the intensity of the reflected echo signal directly, since the wavelength of the ultrasonic effect used is much larger than the particle size. Qualitative theoretical model for the understanding of the experimental results was proposed while taking into account the concept that at the acoustic oscillations of the hydrogel, the macromolecular net, and water in the gel porous structure experience the viscous Stocks-like interaction. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords: BIOMEDICAL APPLICATIONS
FERROGELS
MAGNETIC NANOPARTICLES
MEDICAL ULTRASOUND
SONOGRAPHY
ACRYLIC MONOMERS
AMIDES
BIOMEDICAL ENGINEERING
BLOOD VESSELS
MEDICAL APPLICATIONS
NANOMAGNETICS
PARTICLE SIZE
SYNTHESIS (CHEMICAL)
TARGETED DRUG DELIVERY
ULTRASONOGRAPHY
ACOUSTIC OSCILLATION
BIOMEDICAL APPLICATIONS
CHARACTERIZATION TECHNIQUES
FERROGELS
MAGNETIC NANO-PARTICLES
MAGNETIC NANOPARTI CLES (MNPS)
MEDICAL ULTRASOUND
THEORETICAL MODELING
NANOPARTICLES
MAGNETITE NANOPARTICLE
CHEMISTRY
ECHOGRAPHY
ELASTICITY
GEL
MECHANICAL STRESS
MEDICAL TECHNOLOGY
PROCEDURES
ULTRASTRUCTURE
BIOMEDICAL TECHNOLOGY
ELASTICITY
GELS
MAGNETITE NANOPARTICLES
STRESS, MECHANICAL
ULTRASONOGRAPHY
URI: http://hdl.handle.net/10995/90670
https://elar.urfu.ru/handle/10995/90670
Access: info:eu-repo/semantics/openAccess
cc-by
SCOPUS ID: 85072528897
WOS ID: 000489187800144
PURE ID: 10770829
ISSN: 1424-8220
DOI: 10.3390/s19183959
metadata.dc.description.sponsorship: 18-19-00090
Ministry of Education and Science of the Russian Federation, Minobrnauka: 3.1438.2017/46
Funding: The Russian Scientific Foundation (grant 18-19-00090) supported the experimental parts of this study, including the design, performance and analysis of experiments.
Acknowledgments: A.Yu. Zubarev thanks the program of the Ministry of Education and Science of the Russian Federation (project 3.1438.2017/46) for the support of his mathematical studies. We thank K.R. Mekhdieva, P.A. Shabadrov, V.Ya. Krokhalev, I.V. Beketov and A.M. Murzakaev for special support.
RSCF project card: 18-19-00090
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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