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Название: | Non-poissonian Distribution of Point Mutations in DNA |
Авторы: | Turaeva, N. Oksengendler, B. L. |
Дата публикации: | 2020 |
Издатель: | Frontiers Media S.A. |
Библиографическое описание: | Turaeva, N. Non-poissonian Distribution of Point Mutations in DNA / N. Turaeva, B. L. Oksengendler. — DOI 10.3389/fchem.2020.00038 // Frontiers in Chemistry. — 2020. — Iss. 8. — 38. |
Аннотация: | In general, for chemical reactions occurring in systems, where fluctuations are not negligibly small, it is necessary to introduce a master equation for distribution of probability of fluctuations. It has been established that the monomolecular reactions of a type as A ↔ X are described by the master equation, which leads to a Poisson distribution with the variance equal to the average value N0. However, the consideration of the Löwdin mechanism as autocatalytic non-linear chemical reactions such as A + X ↔ 2X and the corresponding master equation lead to a non-Poissonian probability distribution of fluctuations. In the presented work, first-order autocatalysis has been applied to the Löwdin's mechanism of spontaneous mutations in DNA. Describing double proton transfers between complimentary nucleotide bases along the chain by first-order autocatalytic reactions, the corresponding master equation for protons in tautomeric states becomes non-linear, and at non-equilibrium conditions this leads to the non-Poissonian distribution of spontaneous mutations in DNA. It is also suggested that the accumulation of large fluctuations of successive cooperative concerted protons along the chain may produce higher non-linearities which could have a significant impact on some biochemical processes, occurring in DNA. © Copyright © 2020 Turaeva and Oksengendler. |
Ключевые слова: | AUTOCATALYTIC REACTION DOUBLE PROTON TRANSFER LÖWDIN'S MECHANISM NON-POISSONIAN DISTRIBUTION FUNCTION SPONTANEOUS MUTATION |
URI: | http://elar.urfu.ru/handle/10995/90382 |
Условия доступа: | info:eu-repo/semantics/openAccess cc-by |
Идентификатор SCOPUS: | 85079477741 |
Идентификатор WOS: | 000514901600001 |
Идентификатор PURE: | 12234047 |
ISSN: | 2296-2646 |
DOI: | 10.3389/fchem.2020.00038 |
Располагается в коллекциях: | Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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10.3389-fchem.2020.00038.pdf | 416,29 kB | Adobe PDF | Просмотреть/Открыть |
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