1. Электронный научный архив УрФУ
  2. 00. Общеуниверситетские коллекции
  3. Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC
Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на этот ресурс: http://elar.urfu.ru/handle/10995/90358
Полная запись метаданных
Поле DCЗначениеЯзык
dc.contributor.authorBlazhennikova, I. V.en
dc.contributor.authorKurpyakova, A. F.en
dc.contributor.authorBykov, V. N.en
dc.contributor.authorGeibo, D. S.en
dc.contributor.authorNikiforov, A. S.en
dc.contributor.authorStepanov, A. V.en
dc.contributor.authorCharushin, V. N.en
dc.contributor.authorChupakhin, O. N.en
dc.contributor.authorKotovskaya, S. K.en
dc.contributor.authorRusinov, V. L.en
dc.date.accessioned2020-09-29T09:47:04Z-
dc.date.available2020-09-29T09:47:04Z-
dc.date.issued2015-
dc.identifier.citationExperimental comparative pharmacokinetics of levofloxacin, triazavirine, and related conjugate / I. V. Blazhennikova, A. F. Kurpyakova, V. N. Bykov, D. S. Geibo, et al. . — DOI 10.30906/0869-2092-2015-78-2-34-38 // Eksperimental'naya i Klinicheskaya Farmakologiya. — 2015. — Vol. 2. — Iss. 78. — P. 34-38.en
dc.identifier.issn0869-2092-
dc.identifier.otherhttp://ekf.folium.ru/index.php/ekf/article/download/1595/1590pdf
dc.identifier.other2-3good_DOI
dc.identifier.other162be3a8-da03-4ff4-841a-e54b741f5513pure_uuid
dc.identifier.otherhttp://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=84929024866m
dc.identifier.urihttp://elar.urfu.ru/handle/10995/90358-
dc.description.abstractA comparative study of the pharmacokinetics of levofloxacin and triazavirine as well as 2-memyltMo-6-nitro-l,2,4-triazolo[5,l-ñ]-l,2,4-triazine-7(4r)-ide (3S)-(-)-9-fluoro-2,3-dmydro-3-memyl-10-(4-memylpiperazm-l-yl)-7-oxo-7H-pyri e]-l,4-benzoxazine-6-carboxylic acid (conjugate 2) obtained by conjugation of triazavirine and levofloxacin, representing a new class of pharmacological agents, was carried out in experiments on rats. It is established that conjugate 2 in comparison to individual levofloxacin and triazavirine has a higher relative bioavailability and lower rate of elimination, which can lead to improved effectiveness of therapy at reduced dose and frequency of drug administration.en
dc.format.mimetypeapplication/pdfen
dc.language.isoruen
dc.publisherIzdatel'stvo Meditsinaen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.sourceEksperimental'naya i Klinicheskaya Farmakologiyaen
dc.subjectCONJUGATEen
dc.subjectINTRAMUSCULAR INJECTIONen
dc.subjectLEVOFLOXACINen
dc.subjectPHARMACOKINETICSen
dc.subjectTRIAZAVIRINEen
dc.subject2 METHYLTHIO 6 NITRO L,2,4 TRIAZOLO[5,1 N] 1,2,4 TRIAZINE 7(4F) IDE 9 FLUORO 2,3 DIHYDRO 3 METHYL 10 (4 METHYLPIPERAZIN 1 YL) 7 OXO 7H PYRIDOL [1,2,3 E] 1,4 BENZOXAZINE 6 CARBOXYLIC ACIDen
dc.subjectANTIVIRUS AGENTen
dc.subjectCARBOXYLIC ACIDen
dc.subjectLEVOFLOXACINen
dc.subjectTRIAZAVIRINEen
dc.subjectUNCLASSIFIED DRUGen
dc.subjectANTIINFECTIVE AGENTen
dc.subjectCARBOXYLIC ACIDen
dc.subjectLEVOFLOXACINen
dc.subjectPYRROLE DERIVATIVEen
dc.subjectTRIAZAVIRINen
dc.subjectTRIAZINE DERIVATIVEen
dc.subjectARTICLEen
dc.subjectCOMPARATIVE EFFECTIVENESSen
dc.subjectCONTROLLED STUDYen
dc.subjectDRUG BIOAVAILABILITYen
dc.subjectDRUG CONJUGATIONen
dc.subjectDRUG ELIMINATIONen
dc.subjectNONHUMANen
dc.subjectRATen
dc.subjectANIMALen
dc.subjectBIOAVAILABILITYen
dc.subjectBLOODen
dc.subjectCHEMISTRYen
dc.subjectCOMPARATIVE STUDYen
dc.subjectHALF LIFE TIMEen
dc.subjectINTRAMUSCULAR DRUG ADMINISTRATIONen
dc.subjectMALEen
dc.subjectANIMALSen
dc.subjectANTI-INFECTIVE AGENTSen
dc.subjectAZOLESen
dc.subjectBIOLOGICAL AVAILABILITYen
dc.subjectCARBOXYLIC ACIDSen
dc.subjectHALF-LIFEen
dc.subjectINJECTIONS, INTRAMUSCULARen
dc.subjectLEVOFLOXACINen
dc.subjectMALEen
dc.subjectRATSen
dc.subjectTRIAZINESen
dc.titleExperimental comparative pharmacokinetics of levofloxacin, triazavirine, and related conjugateen
dc.typeArticleen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeinfo:eu-repo/semantics/publishedVersionen
dc.identifier.rsi23070061-
dc.identifier.doi10.30906/0869-2092-2015-78-2-34-38-
dc.identifier.scopus84929024866-
local.affiliationInnovative Pharmaceutical Company Silver Pharm, Industrialnyi prosp. 45a, St. Petersburg, 195279, Russian Federationen
local.affiliationScientific Research Institute of Military Medicine, Ministry of Defense of Russian Federation, ul. Lesoparkovaya, 4, St. Petersburg, 105043, Russian Federationen
local.affiliationI. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of Russian Academy of Sciences, ul. S. Kovalevskoi 22/20, Yekaterinburg, 620041, Russian Federationen
local.affiliationUral Federal University, ul. Mira 19, Yekaterinburg, 620002, Russian Federationen
local.contributor.employeeBlazhennikova, I.V., Innovative Pharmaceutical Company Silver Pharm, Industrialnyi prosp. 45a, St. Petersburg, 195279, Russian Federationru
local.contributor.employeeKurpyakova, A.F., Scientific Research Institute of Military Medicine, Ministry of Defense of Russian Federation, ul. Lesoparkovaya, 4, St. Petersburg, 105043, Russian Federationru
local.contributor.employeeBykov, V.N., Scientific Research Institute of Military Medicine, Ministry of Defense of Russian Federation, ul. Lesoparkovaya, 4, St. Petersburg, 105043, Russian Federationru
local.contributor.employeeGeibo, D.S., Innovative Pharmaceutical Company Silver Pharm, Industrialnyi prosp. 45a, St. Petersburg, 195279, Russian Federationru
local.contributor.employeeNikiforov, A.S., Scientific Research Institute of Military Medicine, Ministry of Defense of Russian Federation, ul. Lesoparkovaya, 4, St. Petersburg, 105043, Russian Federationru
local.contributor.employeeStepanov, A.V., Scientific Research Institute of Military Medicine, Ministry of Defense of Russian Federation, ul. Lesoparkovaya, 4, St. Petersburg, 105043, Russian Federationru
local.contributor.employeeCharushin, V.N., I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of Russian Academy of Sciences, ul. S. Kovalevskoi 22/20, Yekaterinburg, 620041, Russian Federation, Ural Federal University, ul. Mira 19, Yekaterinburg, 620002, Russian Federationru
local.contributor.employeeChupakhin, O.N., I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of Russian Academy of Sciences, ul. S. Kovalevskoi 22/20, Yekaterinburg, 620041, Russian Federation, Ural Federal University, ul. Mira 19, Yekaterinburg, 620002, Russian Federationru
local.contributor.employeeKotovskaya, S.K., I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of Russian Academy of Sciences, ul. S. Kovalevskoi 22/20, Yekaterinburg, 620041, Russian Federation, Ural Federal University, ul. Mira 19, Yekaterinburg, 620002, Russian Federationru
local.contributor.employeeRusinov, V.L., I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of Russian Academy of Sciences, ul. S. Kovalevskoi 22/20, Yekaterinburg, 620041, Russian Federation, Ural Federal University, ul. Mira 19, Yekaterinburg, 620002, Russian Federationru
local.description.firstpage34-
local.description.lastpage38-
local.issue78-
local.volume2-
local.identifier.pure307107-
local.identifier.eid2-s2.0-84929024866-
Располагается в коллекциях:Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

Файлы этого ресурса:
Файл Описание РазмерФормат 
10.30906-0869-2092-2015-78-2-34-38.pdf160,86 kBAdobe PDFПросмотреть/Открыть
Показать базовое описание ресурса Статистика


Все ресурсы в архиве электронных ресурсов защищены авторским правом, все права сохранены.