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http://elar.urfu.ru/handle/10995/90242
Название: | Neuro-Cells therapy improves motor outcomes and suppresses inflammation during experimental syndrome of amyotrophic lateral sclerosis in mice |
Авторы: | de, Munter, J. P. J. M. Shafarevich, I. Liundup, A. Pavlov, D. Wolters, E. C. Gorlova, A. Veniaminova, E. Umriukhin, A. Kalueff, A. Svistunov, A. Kramer, B. W. Lesch, K. -P. Strekalova, T. |
Дата публикации: | 2020 |
Издатель: | Blackwell Publishing Ltd |
Библиографическое описание: | Neuro-Cells therapy improves motor outcomes and suppresses inflammation during experimental syndrome of amyotrophic lateral sclerosis in mice / J. P. J. M. de Munter, I. Shafarevich, A. Liundup, D. Pavlov, et al. . — DOI 10.1111/cns.13280 // CNS Neuroscience and Therapeutics. — 2020. — Vol. 5. — Iss. 26. — P. 504-517. |
Аннотация: | Aims: Mutations in DNA/RNA-binding factor (fused-in-sarcoma) FUS and superoxide dismutase-1 (SOD-1) cause amyotrophic lateral sclerosis (ALS). They were reproduced in SOD-1-G93A (SOD-1) and new FUS[1-359]-transgenic (FUS-tg) mice, where inflammation contributes to disease progression. The effects of standard disease therapy and anti-inflammatory treatments were investigated using these mutants. Methods: FUS-tg mice or controls received either vehicle, or standard ALS treatment riluzole (8 mg/kg/day), or anti-inflammatory drug a selective blocker of cyclooxygenase-2 celecoxib (30 mg/kg/day) for six weeks, or a single intracerebroventricular (i.c.v.) infusion of Neuro-Cells (a preparation of 1.39 × 106 mesenchymal and hemopoietic human stem cells, containing 5 × 105 of CD34+ cells), which showed anti-inflammatory properties. SOD-1 mice received i.c.v.-administration of Neuro-Cells or vehicle. Results: All FUS-tg-treated animals displayed less marked reductions in weight gain, food/water intake, and motor deficits than FUS-tg-vehicle-treated mice. Neuro-Cell-treated mutants had reduced muscle atrophy and lumbar motor neuron degeneration. This group but not celecoxib-FUS-tg-treated mice had ameliorated motor performance and lumbar expression of microglial activation marker, ionized calcium-binding adapter molecule-1 (Iba-1), and glycogen-synthase-kinase-3ß (GSK-3ß). The Neuro-Cells-treated-SOD-1 mice showed better motor functions than vehicle-treated-SOD-1 group. Conclusion: The neuropathology in FUS-tg mice is sensitive to standard ALS treatments and Neuro-Cells infusion. The latter improves motor outcomes in two ALS models possibly by suppressing microglial activation. © 2019 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd |
Ключевые слова: | AMYOTROPHIC LATERAL SCLEROSIS (ALS) FUSED IN SARCOMA (FUS) PROTEIN GLYCOGEN-SYNTHASE KINASE-3ß (GSK-3ß) MICROGLIA ACTIVATION MOUSE STEM CELL THERAPY SUPEROXIDE DISMUTASE-1 (SOD-1) G93A MICE CELECOXIB CELL MARKER COPPER ZINC SUPEROXIDE DISMUTASE GLYCOGEN SYNTHASE KINASE 3BETA IONIZED CALCIUM BINDING ADAPTER MOLECULE 1 RILUZOLE UNCLASSIFIED DRUG AMYOTROPHIC LATERAL SCLEROSIS ANIMAL EXPERIMENT ANIMAL MODEL ANIMAL TISSUE ARTICLE BODY WEIGHT GAIN CONTROLLED STUDY DISEASE EXACERBATION DRUG EFFECT EXPERIMENTAL NEUROLOGIC DISEASE FLUID INTAKE GENE MUTATION HEMATOPOIETIC STEM CELL HUMAN HUMAN CELL INFLAMMATION MALE MESENCHYMAL STEM CELL MOTOR PERFORMANCE MOUSE MSOD1 MOUSE MUSCLE ATROPHY NERVE CELL DEGENERATION NONHUMAN PILOT STUDY STEM CELL TRANSPLANTATION TRANSGENIC MOUSE |
URI: | http://elar.urfu.ru/handle/10995/90242 |
Условия доступа: | info:eu-repo/semantics/openAccess cc-by |
Идентификатор SCOPUS: | 85076897663 |
Идентификатор WOS: | 000503855500001 |
Идентификатор PURE: | 12657001 |
ISSN: | 1755-5930 |
DOI: | 10.1111/cns.13280 |
Сведения о поддержке: | We thank ?5-100? Russian Excellence Program, Prof. Daniel C. Anthony, Diana Babayevskaya, and Arina Kosakova for their highly valuable contribution. ?Neuro-Cells? preparation was provided by Neuroplast BV, Maastricht, Netherlands. |
Располагается в коллекциях: | Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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10.1111-cns.13280.pdf | 2,06 MB | Adobe PDF | Просмотреть/Открыть |
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