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http://elar.urfu.ru/handle/10995/90058
Название: | The local repolarization heterogeneity in the murine pulmonary veins myocardium contributes to the spatial distribution of the adrenergically induced ectopic foci |
Авторы: | Potekhina, V. M. Averina, O. A. Razumov, A. A. Kuzmin, V. S. Rozenshtraukh, L. V. |
Дата публикации: | 2019 |
Издатель: | Springer |
Библиографическое описание: | The local repolarization heterogeneity in the murine pulmonary veins myocardium contributes to the spatial distribution of the adrenergically induced ectopic foci / V. M. Potekhina, O. A. Averina, A. A. Razumov, V. S. Kuzmin, et al. . — DOI 10.1007/s12576-019-00724-2 // Journal of Physiological Sciences. — 2019. — Vol. 6. — Iss. 69. — P. 1041-1055. |
Аннотация: | An atrial tachyarrhythmias is predominantly triggered by a proarrhythmic activity originate from the pulmonary veins (PV) myocardial sleeves; sympathetic or adrenergic stimulation facilitates PV proarrhythmia. In the present study the electrophysiological inhomogeneity, spatiotemporal characteristics of the adrenergically induced ectopic firing and sympathetic nerves distribution have been investigated in a murine PV myocardium to clarify mechanisms of adrenergic PV ectopy. Electrically paced murine PV demonstrate atrial-like pattern of conduction and atrial-like action potentials (AP) with longest duration in the mouth of PV. The application of norepinephrine (NE), agonists of α- and β-adrenergic receptors (ARs) or intracardiac nerves stimulation induced spontaneous AP in a form of periodical bursts or continuous firing. NE- or ARs agonists-induced SAP originated from unifocal ectopic foci with predominant localization in the region surrounding PV mouth, but not in the distal portions of a murine PV myocardium. A higher level of catecholamine content and catecholamine fiber network density was revealed in the PV myocardial sleeves relative to LA appendage. However, no significant local variation of catecholamine content and fiber density was observed in the murine PV. In conclusion, PV mouth region appear to be a most susceptible to adrenergic proarrhythmia in mice. Intrinsic spatial heterogeneity of AP duration can be considered as a factor influencing localization of the ectopic foci in PV. © 2019, The Physiological Society of Japan and Springer Japan KK, part of Springer Nature. |
Ключевые слова: | ACTION POTENTIAL ARRHYTHMIA ECTOPIC FOCI ECTOPIC FOCUS PULMONARY VEINS NORADRENALIN ACTION POTENTIAL ANIMAL BAGG ALBINO MOUSE CARDIAC MUSCLE DRUG EFFECT ELECTROPHYSIOLOGY INNERVATION LUNG MALE MEMBRANE POTENTIAL MOUSE PHYSIOLOGY PULMONARY VEIN VASCULARIZATION ACTION POTENTIALS ANIMALS ELECTROPHYSIOLOGICAL PHENOMENA LUNG MALE MEMBRANE POTENTIALS MICE MICE, INBRED BALB C MYOCARDIUM NOREPINEPHRINE PULMONARY VEINS |
URI: | http://elar.urfu.ru/handle/10995/90058 |
Условия доступа: | info:eu-repo/semantics/openAccess |
Идентификатор SCOPUS: | 85074998049 |
Идентификатор WOS: | 000496208500001 |
Идентификатор PURE: | 11443413 |
ISSN: | 1880-6546 |
DOI: | 10.1007/s12576-019-00724-2 |
Сведения о поддержке: | 18-34-00931 The study is supported by RFBR 18-34-00931 grant. AP Action potentials AR Adrenergic receptors EAD Early afterdepolarization DAD Delayed afterdepolarization DD Diastolic depolarization SAP Spontaneous action potentials RMP Resting membrane potentials LA Left atria LAA Left atria appendage PKA Proteinkinase A PV Pulmonary veins PNS Postganglionic nerves stimulation NCX Natrium-sodium exchanger NE Norepinephrine PHE Phenylephrine ISO Isoproterenole |
Располагается в коллекциях: | Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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10.1007-s12576-019-00724-2.pdf | 6,2 MB | Adobe PDF | Просмотреть/Открыть |
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