Detailed Electromechanical Model of Ventricular Wedge

Abstract

We developed a three-dimensional computational model for describing electro-mechanical behavior of wedge-shaped preparation extracted from the left ventricular wall including excitation wave propagation, high-resolution geometry and fiber orientation. The cardiac tissue is simulated by an incompressible hyperplastic material. We used non-linear partial differential equations describing the deformation of the cardiac tissue, and a detailed 'Ekaterinburg-Oxford' (EO) cellular model of the electrical and mechanical activity of the cardiomyocytes in the tissue. Electro-mechanical coupling in the model accounts for mechano-electric feedbacks both in the cells and in the tissue. Numerical experiments with the model of the wedge preparation formed of initially identical cardiomyocytes revealed that electrical and mechanical interaction between the cells, as well as intracellular mechanoelectric feedbacks caused pronounced nonuniformity of their behavior. © 2018 Creative Commons Attribution.