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Название: Drift of scrollwaves in a mathematical model of a heterogeneous human heart left ventricle
Авторы: Pravdin, S.
Konovalov, P.
Dierckx, H.
Solovyova, O.
Panfilov, A. V.
Дата публикации: 2020
Издатель: MDPI AG
Библиографическое описание: Drift of scrollwaves in a mathematical model of a heterogeneous human heart left ventricle / S. Pravdin, P. Konovalov, H. Dierckx, O. Solovyova, et al. . — DOI 10.3390/MATH8050776 // Mathematics. — 2020. — Vol. 5. — Iss. 8. — 776.
Аннотация: Rotating spiral waves of electrical excitation underlie many dangerous cardiac arrhythmias. The heterogeneity of myocardium is one of the factors that affects the dynamics of such waves. In this paper, we present results of our simulations for scroll wave dynamics in a heterogeneous model of the human left ventricle with analytical anatomically based representation of the geometry and anisotropy. We used a set of 18 coupled differential equations developed by ten Tusscher and Panfilov (TP06 model) which describes human ventricular cells based on their measured biophysical properties. We found that apicobasal heterogeneity dramatically changes the scroll wave dynamics. In the homogeneous model, the scroll wave annihilates at the base, but the moderate heterogeneity causes the wave to move to the apex and then continuously rotates around it. The rotation speed increased with the degree of the heterogeneity. However, for large heterogeneity, we observed formation of additional wavebreaks and the onset of complex spatio-temporal patterns. Transmural heterogeneity did not change the dynamics and decreased the lifetime of the scroll wave with an increase in heterogeneity. Results of our numerical experiments show that the apex may be a preferable location of the scroll wave, which may be important for development of clinical interventions. © 2020 by the authors.
Ключевые слова: HEART MODELING
HETEROGENEITY
LEFT VENTRICLE
MYOCARDIUM
SPIRAL WAVE
URI: http://elar.urfu.ru/handle/10995/90044
Условия доступа: info:eu-repo/semantics/openAccess
cc-by
Идентификатор SCOPUS: 85085639132
Идентификатор WOS: 000542738100101
Идентификатор PURE: 12915247
ISSN: 2227-7390
DOI: 10.3390/MATH8050776
Сведения о поддержке: AAAA-A18-118020590031-8
Russian Foundation for Basic Research, RFBR: 18-29-13008
Russian Science Foundation, RSF: 14-35-00005
Ural Federal University, UrFU
P.K., S.P., O.S., and A.V.P. were funded by the Russian Science Foundation (project 14-35-00005). A.V.P., P.K., and O.S. were funded by the Russian Foundation for Basic Research (#18-29-13008). A.V.P. and O.S. were funded by RF Government Act #211 of 16 March 2013 (agreement 02. A03.21.0006). P.K. and O.S. work was carried out within the framework of the IIF UrB RAS theme No. AAAA-A18-118020590031-8. A.V.P. and H.D. were partially funded by BOF Ghent University. Simulations were performed at the supercomputer Uran of Institute of Mathematics and Mechanics (Ekaterinburg, Russia) and at the supercomputer of Ural Federal University (Ekaterinburg, Russia).
Располагается в коллекциях:Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

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