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  3. Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC
Please use this identifier to cite or link to this item: http://elar.urfu.ru/handle/10995/89992
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dc.contributor.authorRyvkin, A.en
dc.contributor.authorMarkov, N.en
dc.date.accessioned2020-09-29T09:45:33Z-
dc.date.available2020-09-29T09:45:33Z-
dc.date.issued2018-
dc.identifier.citationRyvkin, A. Ryanodine Receptors Coupling Causes a Calcium Leak in Cardiac Cell / A. Ryvkin, N. Markov. — DOI 10.22489/CinC.2018.323 // Computing in Cardiology. — 2018. — Iss. 2018-September. — 8743850.en
dc.identifier.isbn9781728109589-
dc.identifier.issn2325-8861-
dc.identifier.otherhttps://doi.org/10.22489/cinc.2018.323pdf
dc.identifier.other1good_DOI
dc.identifier.other5594eebe-ed96-4c42-8578-9d43e557c9aapure_uuid
dc.identifier.otherhttp://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85068768326m
dc.identifier.urihttp://elar.urfu.ru/handle/10995/89992-
dc.description.abstractHere we introduce results of a mathematical modeling of calcium sparks in cardiac cells. We developed a model of the calcium release unit which includes a single sarcoplasmic reticulum (SR) lumen, a regular 9×9 cluster of RyRs and a dyadic space. 2D diffusion problem of Ca2+ ions across the dyadic space was solved thereby we reproduced Calcium-fnduced-Calcium-Release (CICR) effect and domino-like RyRs activation in the cluster. We take into account allosteric and Ca2+-induced coupling between RyRs. We show, that coupling between RyRs leads to the stability of Ca2+ sparks in amplitude and frequency. However, a sudden stop of spontaneous Ca2+ releases can be a result of strong allosteric coupling between RyRs. © 2018 Creative Commons Attribution.en
dc.description.sponsorshipRussian Foundation for Basic Research, RFBR: 16-34-60223en
dc.description.sponsorshipThe project is supported by RFBR grant 16-34-60223. The work was carried out within the framework of the IIF UrB RAS theme No AAAA-A18-118020590031-8 and RF Government Act 211 of March 16, 2013 (agreement 02.A03.21.0006).en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherIEEE Computer Societyen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.sourceComputing in Cardiologyen
dc.subjectCARDIOLOGYen
dc.subjectALLOSTERIC COUPLINGen
dc.subjectCALCIUM RELEASEen
dc.subjectCARDIAC CELLen
dc.subjectDIFFUSION PROBLEMSen
dc.subjectRYANODINE RECEPTORSen
dc.subjectSARCOPLASMIC RETICULUMen
dc.subjectCALCIUMen
dc.titleRyanodine Receptors Coupling Causes a Calcium Leak in Cardiac Cellen
dc.typeConference Paperen
dc.typeinfo:eu-repo/semantics/conferenceObjecten
dc.typeinfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.22489/CinC.2018.323-
dc.identifier.scopus85068768326-
local.affiliationInstiute of Immunology Physiology UrB RAS, Pervomayskaya 106, Ekarerinburg, 620000, Russian Federationen
local.affiliationUral Federal University, Ekaterinburg, Russian Federationen
local.contributor.employeeRyvkin, A., Instiute of Immunology Physiology UrB RAS, Pervomayskaya 106, Ekarerinburg, 620000, Russian Federation, Ural Federal University, Ekaterinburg, Russian Federationru
local.contributor.employeeMarkov, N., Instiute of Immunology Physiology UrB RAS, Pervomayskaya 106, Ekarerinburg, 620000, Russian Federationru
local.issue2018-September-
dc.identifier.wos000482598700127-
local.identifier.pure10261889-
local.description.order8743850-
local.identifier.eid2-s2.0-85068768326-
local.fund.rffi16-34-60223-
local.identifier.wosWOS:000482598700127-
Appears in Collections:Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

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